Products Buprenorphine is commercially available as sublingual tablets, transdermal patch and injection solution, and depot injection solution (e.g., Temgesic, Transtec, Subutex, generics). It has been approved in many countries since 1979. Structure and properties Buprenorphine (C29H41NO4, Mr = 467.6 g/mol) is present in drugs as buprenorphine hydrochloride, a white crystalline powder that is sparingly soluble … Buprenorphine
Products Butamirate is commercially available as a syrup, drops, and depot tablets (e.g., NeoCitran cough suppressant, formerly Sinecod). It has been approved in many countries since 1965. Structure and properties Butamirate (C18H29NO3, Mr = 307.4 g/mol) is present in drugs as butamirate dihydrogen citrate. It has structural similarities to the antitussive butetamate. Butamirate is not … Butamirate
Products Pregabalin is commercially available in capsule form and as an oral solution (Lyrica, generics). It was approved in the United States and EU in 2004 and in many countries in 2005. Structure and properties Pregabalin (C8H17NO2, Mr = 159.2 g/mol) exists as a white crystalline powder that is soluble in water. It was developed … Pregabalin
Products Alfentanil is commercially available as a solution for injection (Rapifen). It has been approved in many countries since 1983. Structure and properties Alfentanil (C21H32N6O3, Mr = 416.5 g/mol) is a 4-anilidopiperidine and a tetrazole derivative. It is present in the drug as alfentanil hydrochloride, a white powder that is readily soluble in water. The … Alfentanil
Products Clotiapine is commercially available in tablet form (Entumin). It has been approved in many countries since 1967. Structure and properties Clotiapine (C18H18ClN3S, Mr = 343.87 g/mol) is a dibenzothiazepine. The structurally closely related neuroleptic quetiapine (Seroquel) also belongs to this group of drugs. Effects Clotiapine (ATC N05AH06) has adrenolytic, antidopaminergic, anticholinergic, antihistamine, sedative, psychomotor … Clotiapine
Products Dimenhydrinate is commercially available in the form of tablets, dragées, [chewing gum dragées>chewing gum], and capsules, among others. Since 2012, a combination with the calcium channel blocker cinnarizine has been approved in many countries (Arlevert) see under Cinnarizine and Dimenhydrinate. Structure and properties Dimenhydrinate (C24H28ClN5O3, Mr = 470.0 g/mol) is the salt of diphenhydramine … Dimenhydrinate
Products Dimetinden maleate is available as oral drops (Feniallerg drops). They were formerly called Fenistil drops. The drug has been approved in many countries since 1961. Structure and properties Dimetindene (C20H24N2, Mr = 292.4 g/mol) is present in drugs as dimetindene maleate, a white crystalline powder that is poorly soluble in water. The name is … Dimetinden Maleate Drops
Products Anxiolytics are commercially available in the form of tablets, capsules, and injectable preparations, among others. Structure and properties Anxiolytics are a structurally heterogeneous group. However, the representatives can be divided into different classes. These include, for example, the benzodiazepines or the tricyclic antidepressants. Effects Anxiolytics have antianxiety (anxiolytic) properties. They usually have additional effects, … Anxiolytics
Products Ketazolam is commercially available in capsule form (Solatran). It has been approved in many countries since 1980. Structure and properties Ketazolam (C20H17ClN2O3, Mr = 368.8 g/mol) structurally belongs to the 1,4-benzodiazepines. Effects Ketazolam (ATC N05BA10) has antianxiety, depressant, muscle relaxant, and anticonvulsant properties. The effects are due to binding to GABA-A receptors and enhancement … Ketazolam
Products Orexin receptor antagonists are commercially available in tablet form. The first agent in this group to be approved in the United States was suvorexant (Belsomra) in 2014. Lemborexant (Dayvigo) followed in 2019. Structure and properties Orexin receptor antagonists are characterized by a central ring structure to which heterocycles are attached on both sides. Effects … Orexin Receptor Antagonists
Products Methaqualone was launched in the 1960s and is now off the market in many countries. Toquilone compositum (fixed combination with diphenhydramine) was withdrawn from the market in late 2005. Methaqualone is now one of the more tightly controlled narcotics (schedule a). Structure and properties Methaqualone (C16H14N2O, Mr = 250.3 g/mol) is a quinazoline derivative. … Methaqualone
Products The cannabis oral spray Sativex was approved in many countries in 2013. It is subject to narcotics legislation and requires an enhanced prescription. In Germany, Sativex has been available since 2011. Structure and properties The oral spray contains a thick extract of the hemp plant L., which is extracted from the leaves and flowers … Cannabis Mouth Spray