Products Gemfibrozil is commercially available in the form of film-coated tablets (Gevilon, Gevilon Uno). It has been approved in many countries since 1985. Structure and properties Gemfibrozil (C15H22O3, Mr = 250.3 g/mol) exists as a white powder that is practically insoluble in water. Effects Gemfibrozil (ATC C10AB04) has lipid-lowering properties. It lowers VLDL, triglycerides, total … Gemfibrozil
Products Apalutamide was approved in the US and EU in 2018 and in many countries in 2019 in film-coated tablet form (Erleada). Structure and properties Apalutamide (C21H15F4N5O2S, Mr = 477.4 g/mol) exists as a white to slightly yellow powder that is practically insoluble in water. The active metabolite -demethylapalutamide is also active, but more weakly … Apalutamide
Products Repaglinide is commercially available in tablet form (NovoNorm, generic). It was approved in many countries in 1999. Structure and properties Repaglinide (C27H36N2O4, Mr = 452.6 g/mol) is a meglitinide and carbamoylmethylbenzoic acid derivative without sulfonylurea structure. It is a white, odorless powder that is practically insoluble in water due to its lipophilicity. In drugs, … Repaglinide
Products Remdesivir is commercially available as a powder for a concentrate for the preparation of an infusion solution (Veklury, Gilead Sciences Inc, USA). Provisional approval was granted in many countries and in the EU in July 2020. On November 25, 2020, the approval will be granted. In the U.S., the drug was registered in October. … Remdesivir
Products Paclitaxel is commercially available as an infusion concentrate (Taxol, generic). It has been approved in many countries since 1993. The active ingredient itself is also known as taxol. Protein-bound nab-paclitaxel (Abraxane) was approved in many countries in 2014. Structure and properties Paclitaxel (C47H51NO14, Mr = 853.9 g/mol) is a complex tetracyclic diterpene. It exists … Paclitaxel
Products Enzalutamide was initially registered in capsule form (Xtandi). Film-coated tablets were approved in many countries in 2019. They are smaller and therefore easier to take. Enzalutamide was approved in the United States in 2012 and in many countries and the EU in 2013. Structure and properties Enzalutamide (C21H16F4N4O2S, Mr = 464.4 g/mol) is an … Enzalutamide
Products Loperamide is commercially available in the form of capsules, film-coated tablets, melting tablets, and as a syrup (Imodium, generic). It has been approved in many countries since 1977. Structure and properties Loperamide (C29H33ClN2O2, Mr = 477.0 g/mol) is a piperidine derivative and has structural similarities to the neuroleptic haloperidol and the peristaltic inhibitor diphenoxylate. … Loperamide: Drug Effects, Side Effects, Dosage and Uses
Products Rosiglitazone was commercially available in tablet form (Avandia). It had been approved since 1999 and was also commercially available in fixed combination with the biguanide metformin (Avandamet). The combination with the sulfonylurea glimepiride (Avaglim, EU, off-label) was not approved in many countries. A publication in on possible cardiovascular risks led to a controversy about … Rosiglitazone
Products Dabrafenib was approved in the US and EU in 2013 and in many countries in 2014 in hard capsule form (Tafinlar). Structure and properties Dabrafenib (C23H20F3N5O2S2, Mr = 519.6 g/mol) is present in drugs as dabrafenib mesilate, a white to slightly colored powder that is practically insoluble in water. It is a thiazole and … Dabrafenib
Products Amiodarone is commercially available in tablet form and as a solution for injection (Cordarone, generics). It has been approved in many countries since 1968. Structure and properties Amiodarone (C25H29I2NO3, Mr = 645.3 g/mol) is an iodinated benzofuran derivative derived from khellin. It is present in drugs as amiodarone hydrochloride, a white, fine, crystalline powder … Amiodarone (Nexterone) for Arrhythmia
Products Alitretinoin is commercially available in capsule form (Toctino) and was approved in many countries in 2009. Structure and properties Alitretinoin (C20H28O2, Mr = 300.4 g/mol) is a retinoid like the acne drugs isotretinoin (13- retinoic acid) or tretinoin (all-retinoic acid). Effects Alitretinoin (ATC D11AX19) has anti-inflammatory and immunomodulatory properties. Unlike other retinoids, it acts … Alitretinoin
Products Teriflunomide is commercially available in the form of film-coated tablets (Aubagio). It was approved in many countries in 2013. Teriflunomide can be taken perorally, unlike earlier MS medications, and does not need to be injected. Structure and properties Teriflunomide (C12H9F3N2O2, Mr = 270.2 g/mol) is the active metabolite of the prodrug leflunomide (Arava), which … Teriflunomide
