Products Azilsartan has been approved in the United States and the EU in tablet form since 2011 (Edarbi). In many countries, it was registered in August 2012 as the 8th member of the sartan drug group. In 2014, a fixed combination with chlortalidone was approved (Edarbyclor). Structure Azilsartan (C25H20N4O5, Mr = 456.5 g/mol) is present … Azilsartan
Products Ritonavir is commercially available as a monopreparation in the form of film-coated tablets (Norvir). It was approved in many countries, in the United States and in the EU in 1996, and is also used as a pharmacokinetic booster in combination with antiviral agents (eg, lopinavir). Norvir syrup is no longer marketed in many countries. … Ritonavir
Products Meloxicam was commercially available in tablet form (Mobicox). It was approved in many countries since 1995. It was discontinued from distribution in 2016. Structure and properties Meloxicam (C14H13N3O4S2, Mr = 351.4 g/mol) belongs to the oxicams and is a thiazole and a benzothiazine derivative. It exists as a yellow powder that is practically insoluble … Meloxicam
Products Carvedilol is commercially available in tablet form (Dilatrend, generic). It has been approved in many countries since 1995. Carvedilol is also combined with ivabradine fixed (Carivalan). Structure and properties Carvedilol (C24H26N2O4, Mr = 406.5 g/mol) is a racemate, with both enantiomers participating in the pharmacological effects. It exists as a white crystalline powder that … Carvedilol
Products Efavirenz is commercially available as film-coated tablets and as an oral solution (Stocrin, combination products, generics). It has been approved in many countries since 2001. Structure and properties Efavirenz (C14H9ClF3NO2, Mr = 315.7 g/mol) exists as a white to light pink crystalline powder that is practically insoluble in water. It has a non-nucleoside structure … Efavirenz
Products Oritavancin was approved in the United States in 2014 as an infusion preparation (Orbactiv). The drug has not yet been registered in many countries. Structure and properties Oritavancin is present in drugs as oritavancin phosphate (C86H97N10O26Cl3 – 2H3PO4, Mr = 1989.1 g/mol) is present, a complex semisynthetically produced lipoglycopeptide structurally related to other glycopeptide … Oritavancin
Products Gliclazide has been commercially available in sustained-release tablet form and approved in many countries since 1978. The sustained-release dosage forms entered the market in 2001. In addition to the original Diamicron MR, sustained-release generics have been available since 2008. Sales of the non-retarded Diamicron 80 mg were discontinued in 2012. Structure and properties Gliclazide … Gliclazide
Products Glimepiride is commercially available in tablet form (Amaryl, generic). It has been approved in many countries since 1995. Structure and properties Glimepiride (C24H34N4O5S, Mr = 490.62 g/mol) exists as a white to yellowish-white, crystalline and odorless powder that is practically insoluble in water. It belongs structurally to the sulfonylureas. Effects Glimepiride (ATC A10BB12) has … Glimepiride
Products Vardenafil is commercially available in the form of film-coated tablets and oral tablets (Levitra, co-marketing drug: Vivanza). It has been approved in many countries since 2003. Generic versions were approved in 2018. Structure and properties Vardenafil (C23H32N6O4S, Mr = 488.6 g/mol) is present in the drugs as vardenafil hydrochloride trihydrate, a piperazine derivative and … Vardenafil
Products Noscapine is commercially available in the form of lozenges, capsules, drops, as a syrup, and as suppositories. Except for Tussanil N, the drugs are combination products. Structure and properties The phthalideisoquinoline noscapine (C22H23NO7, Mr = 413.4 g/mol) is present in drugs as a free base or as noscapine hydrochloride monohydrate. Noscapine is a white … Noscapine
Products Nateglinide is commercially available in the form of film-coated tablets (Starlix, Starlix mite). It has been approved in many countries since 2000. Structure and properties Nateglinide (C19H27NO3, Mr = 317.42 g/mol) is a cyclohexane derivative of the amino acid phenylalanine. It is a white powder that is practically insoluble in water. Effects Nateglinide (ATC … Nateglinide
Products Sildenafil is commercially available in the form of film-coated tablets and as a solution for injection (Viagra, Revatio, generics). It has been approved in many countries since 1998. Generics went on sale July 22, 2013, and the patent expired June 21. Pfizer launched auto-generic sildenafil Pfizer, identical to the original, back in May. In … Sildenafil
