Products Lomitapide is commercially available in capsule form (Juxtapid, Lojuxta). It was approved in the United States in 2012 and in the EU in 2013. The drug has not yet been registered in many countries. Structure and properties Lomitapide (C39H37F6N3O2, Mr = 693.7 g/mol) is present in the drug as lomitapide mesilate, a white powder … Lomitapide
Products The active ingredient fluticasone has been approved in many countries since 1994 and is included in numerous drugs: Powder inhalers (Arnuity Ellipta, Seretide + salmeterol, Relvar Ellipta + vilanterol, Trelegy Ellipta + vilanterol + umeclidinium bromide). Metered dose inhalers (Axotide, Seretide + salmeterol, Flutiform + formoterol). Nasal sprays (Avamys, Nasofan, Dymista + azelastine). Nasal … Fluticasone
Products Ticagrelor is commercially available in the form of film-coated tablets (Brilique). The active ingredient was approved in many countries in 2011. In 2018, additional meltable tablets were registered. Structure and properties Ticagrelor (C23H28F2N6O4S, Mr = 522.6 g/mol) is a cyclopentyltriazolopyrimidine without a thienopyridine structure. Ticagrelor is directly active. It has an active metabolite but, … Ticagrelor
Products Domperidone is commercially available as film-coated tablets, lingual tablets, and as a suspension (Motilium, generics). It was synthesized in 1974 and has been approved in many countries since 1979. Structure and properties Domperidone (C22H24ClN5O2, Mr = 425.9 g/mol) exists as a white powder that is practically insoluble in water. It is a benzimidazole derivative … Domperidone
Effects Nasal glucocorticoids are antiallergic, anti-inflammatory, and decongestant by locally inhibiting the synthesis of inflammatory mediators. They reduce nasal symptoms such as runny or stuffy nose, itching, sneezing, and sneezing, and may also have a beneficial effect on ocular symptoms such as itching, burning, redness, and tearing. In contrast to oral glucocorticoids, there are significantly … Glucocorticoid Nasal Sprays
Products Terfenadine (Teldane tablets/suspension) is no longer on the market in many countries. Possible alternatives are the successor product fexofenadine (Telfast) or other 2nd generation antihistamines. Structure and properties Terfenadine (C32H41NO2, Mr = 471.7 g/mol) is a racemate. It exists as a white crystalline powder that is very sparingly soluble in water. Terfenadine is a … Terfenadine
Products Sertindole is commercially available in the form of film-coated tablets (Serdolect). It has been approved in many countries since 1997. Structure and properties Sertindole (C24H26ClFN4O, Mr = 440.9 g/mol) was developed as the first neuroleptic with a phenylindole structure. Effects Sertindole (ATC N05AE03) has antipsychotic properties. The effects are due to antagonism at dopamine … Sertindol
Products Ranolazine is commercially available in the form of sustained-release tablets (Ranexa). It was approved in the United States as early as 2006, in the EU in July 2008, and in many countries in April 2010. Structure and properties Ranolazine or ()–(2, 6-dimethylphenyl)-4(2-hydroxy-3-(2-methoxyphenoxy)-propyl)-1-piperazine acetamide (C24H33N3O4, Mr = 427.54 g/mol) is a piperazine derivative and a … Ranolazine
Products Fesoterodine is commercially available in the form of sustained-release tablets (Toviaz). It has been approved in the EU since 2007 and in many countries since 2008. Structure and properties Fesoterodine (C26H37NO3, Mr = 411.58 g/mol) is present in drugs as fesoterodine fumarate. It is an ester prodrug and is rapidly and completely hydrolyzed to … Fesoterodine
Products Ubrogepant was approved in the United States in 2019 in tablet form (Ubrelvy). Structure and properties Ubrogepant (C29H26F3N5O3, Mr = 549.6 g/mol) exists as a white powder that is practically insoluble in water. Effects Ubrogepant has analgesic properties and is effective against other symptoms of migraine such as photophobia (sensitivity to light), phonophobia (sensitivity … Ubrogepant
Products Clobetasol propionate is commercially available as cream, ointment, foam, shampoo, and scalp application (Dermovate, Clobex, Clarelux). It has been approved in many countries since 1976. Structure and properties Clobetasol propionate (C25H32ClFO5, Mr = 466.97 g/mol) is the ester of clobetasol with propionic acid. It is a derivative of prednisolone. Clobetasol propionate exists as a … Clobetasol Propionate
Products Desfesoterodine was approved in many countries in 2019 in sustained-release tablet form (generic, tovedeso). Structure and properties Desfesoterodine (C22H31NO2, Mr = 341.5 g/mol) is the active metabolite of the prodrug fesoterodine as well as tolterodine (detrusitol). It is also referred to as 5-hydroxymethyltolterodine. In the drug, it is present as desfesoterodine succinate. Effects Desfesoterodine … Desfesoterodine
