Products Pertuzumab is commercially available as a concentrate for the preparation of an infusion solution (Perjeta). It was approved in many countries in 2012. Structure and properties Pertuzumab is a recombinant humanized IgG1 monoclonal antibody. It was developed as a successor to trastuzumab (Herceptin). Effects Pertuzumab (ATC L01XC13) has cytostatic and antiproliferative properties. The effects … Pertuzumab
Products Decitabine is commercially available as a lyophilizate for the preparation of a concentrate for infusion solution (Dacogen). It has been approved in many countries and in the EU since 2012. Structure and properties Decitabine (C8H12N4O4, Mr = 228.2 g/mol) or 5-aza-2′-deoxycytidine is an analog of cytidine deoxynucleoside and differs from deoxycytidine by a C … Decitabine
Products Estramustine phosphate is commercially available in the form of capsules (Estracyt). It has been approved in many countries since 1977. Structure and properties Estramustine phosphate (C23H30Cl2NNa2O6P, Mr = 564.3 g/mol) is an estradiol phosphate ester linked via a carbamate linkage to noritrogen solstice, and is a prodrug. Effects Estramustine phosphate (ATC L01XX11) has cytostatic … Estramustine Phosphate
Products Trabectedin is commercially available as a powder for the preparation of an infusion solution concentrate (Yondelis). It has been approved in many countries since 2009. Structure and properties Trabectedin (C39H43N3O11S, Mr = 761.8 g/mol) is a tetrahydroisoquinoline alkaloid from sea squirt , a marine animal belonging to the tunicates. The active ingredient is produced … Trabectedin
Background Kinases (phosphotransferases) are a large family of enzymes involved in the transduction and amplification of signals on and in cells. They exert their effects by phosphorylating their substrates, that is, by adding a phosphate group to the molecules (Figure). Kinases have complicated names that are usually abbreviated: ALK, AXL, BCR-ABL, c-Kit, c-Met, ERBB, EGFR, … Kinase Inhibitors
Products Methotrexate is commercially available as a solution for parenteral use and in tablet form. See also under methotrexate prefilled syringe (low-dose). Structure and properties Methotrexate (C20H22N8O5, Mr = 454.44 g/mol) is a dicarboxylic acid that exists as a yellow to orange crystalline powder that is virtually insoluble in water. Methotrexate was developed as a … Methotrexate: Drug Effects, Side Effects, Dosage and Uses
Products Prefilled methotrexate syringes have been approved in many countries since 2005 (Metoject, generic). They contain between 7.5 to 30 mg of active ingredient, in increments of 2.5 mg. The dose is much lower than for chemotherapy (“low-dose methotrexate“). The syringes are stored at room temperature between 15 to 25 °C and protected from light. … Methotrexate Ready-To-Use Syringe
Products Temozolomide is commercially available as capsules and as a powder for the preparation of an infusion solution (Temodal, generics). It has been approved in many countries since 1999. Structure and properties Temozolomide (C6H6N6O2, Mr = 194.2 g/mol) is an imidazotetrazine derivative. It is a prodrug that is biotransformed by hydrolysis to the active metabolite … Temozolomide
Products Dactinomycin was commercially available as a lyophilizate (Cosmegen). It was approved in many countries since 1966 and was withdrawn from the market in 2012 on November 30 for commercial reasons. It can be imported from abroad if needed. Structure and properties Dactinomycin (C62H86N12O16, Mr = 1255.4 g/mol) is an actinomycin and phenoxazone derivative formed … Dactinomycin
Products Granisetron is commercially available as film-coated tablets and as an infusion concentrate (Kytril, generic). It has been approved in many countries since 1991. A transdermal patch was approved in the EU in 2012 (Sancuso). Structure and properties Granisetron (C18H24N4O, Mr = 312.4 g/mol) is an indazole derivative. It is present in drugs as granisetron … Granisetron
Products Ixabepilone is commercially available as an infusion preparation (Ixempra). It has been approved in many countries since 2009. Effects Ixabepilone (ATC L01DC04) has cytostatic and antitumor properties. Indications Breast cancer
Products Medicines containing dithranol are no longer on the market in many countries. They can be imported from abroad or prepared as extemporaneous preparations in a pharmacy. Corresponding regulations can be found, for example, in the DMS. Dithranol is incorporated into petrolatum and thick kerosene, for example. Structure Dithranol (C14H10O3, Mr = 226.2 g/mol) is … Dithranol
