Products Antazoline is fixed combination with tetryzoline in the form of eye drops commercially available (Spersallerg, Spersallerg SDU). It has been approved in many countries since 1967. Structure and properties Antazoline (C17H19N3, Mr = 265.35 g/mol) is present in drugs as antazoline hydrochloride, a white crystalline powder that is sparingly soluble in water. It is … Antazoline: Antihistamine
Products Olanzapine is commercially available as film-coated tablets, meltable tablets, and powder for solution for injection (Zyprexa, generics). It has been approved in the U.S. and EU since 1996 and in many countries since 1997. Generic versions entered the market in 2012. Structure and properties Olanzapine (C17H20N4S, Mr = 312.4 g/mol) belongs to the thienobenzodiazepine … Olanzapine
Products Dimetinden maleate is commercially available as drops, gel, lotion, nasal spray, and nasal drops (Fenistil, Feniallerg, Vibrocil, Otriduo). The nasal products also contain the vasoconstrictor phenylephrine. The Fenistil products used internally (systemically) were renamed Feniallerg in 2009. The capsules and dragées are no longer available. Structure and properties Dimetind (C20H24N2, Mr = 292.4 g/mol) … Dimetindenmaleate
Products Dimetinden maleate has been commercially available in many countries since 1974 in the form of a gel (Fenistil Gel). Structure and properties Dimetindene (C20H24N2, Mr = 292.4 g/mol) is present in drugs as dimetindene maleate, a white crystalline powder that is poorly soluble in water. The name is derived from the two methyl groups … Dimetinden Maleate Gel
Products Dimetinden maleate is available as oral drops (Feniallerg drops). They were formerly called Fenistil drops. The drug has been approved in many countries since 1961. Structure and properties Dimetindene (C20H24N2, Mr = 292.4 g/mol) is present in drugs as dimetindene maleate, a white crystalline powder that is poorly soluble in water. The name is … Dimetinden Maleate Drops
Products Olopatadine is commercially available in the form of eye drops (Opatanol). It has been approved in many countries since 2003. Structure and properties Olopatadine (C21H23NO3, Mr = 337.41 g/mol) is present in drugs as olopatadine hydrochloride. It is a dihydrodibenzoxepin derivative with a tricyclic structure. Effects Olopatadine (ATC S01GX09) has antihistamine, antiallergic, and mast … Olopatadine
Products Ketanserin is commercially available as a gel (Vulketan). It has been approved in many countries since 1995 and exclusively as a veterinary drug. In other countries, it is also available for human use as an antihypertensive. Structure and properties Ketanserin (C22H22FN3O3, Mr = 395.4 g/mol) is a quinazolinone derivative. Ketanserin hydrogenotartrate is used in … Ketanserin
Products Astemizole was commercially available in tablet and suspension form (Hismanal). It has been withdrawn from the market in many countries because of potential adverse effects and is no longer available (see below). It may well be replaced by other, better-tolerated antihistamines, such as cetirizine, loratadine, and fexofenadine. Structure and properties Astemizole (C28H31FN4O, Mr = … Astemizole
Products Drug product containing acrivastine is no longer available in many countries. Semprex capsules are out of trade. Structure and properties Acrivastine (C22H24N2O2, Mr = 348.44 g/mol) is a derivative of the antihistamine triprolidine (not commercially available). It exists as an odorless, white, crystalline powder that is somewhat sparse in water. Acrivastine belongs to the … Acrivastin
Products Pheniramine is contained in combination with other active ingredients in NeoCitran powder, which has been approved in many countries since 1985. Structure and properties Pheniramine (C16H20N2, Mr = 240.3 g/mol) is present in drugs as pheniramine maleate, a white crystalline powder that is very soluble in water. It is a racemate and an alkylamine … Pheniramine
Products Terfenadine (Teldane tablets/suspension) is no longer on the market in many countries. Possible alternatives are the successor product fexofenadine (Telfast) or other 2nd generation antihistamines. Structure and properties Terfenadine (C32H41NO2, Mr = 471.7 g/mol) is a racemate. It exists as a white crystalline powder that is very sparingly soluble in water. Terfenadine is a … Terfenadine
Products Dibenzepine was still commercially available as extended-release film-coated tablets (Noveril TR, Novartis, formerly Wander). It was approved in many countries in 1968 and withdrawn from the market in 2016. Structure and properties Dibenzepine (C18H21N3O, Mr = 295.4 g/mol) is present in drugs as dibenzepine hydrochloride. It belongs to the dibenzepine group. Effects Dibenzepine (ATC … Dibenzepine
