Products Darifenacin is commercially available in the form of sustained-release tablets (Emselex). It has been approved in many countries since 2005. Structure and properties Darifenacin (C28H30N2O2, Mr = 426.6 g/mol) is a tertiary amine. It is present in drugs as darifenacin hydrobromide, a white crystalline powder. Effects Darifenacin (ATC G04BD10) has parasympatholytic properties. It is … Darifenacin
Products Darolutamide was approved in the US in 2019 and in the EU and Switzerland in 2020 in film-coated tablet form (Nubeqa). Structure and properties Darolutamide (C19H19ClN6O2, Mr = 398.8 g/mol) exists as a white to grayish or yellowish-white crystalline powder and is practically insoluble in water. The drug has a nonsteroidal structure and is … Darolutamide
Products Dasatinib is commercially available in the form of film-coated tablets (Sprycel). It has been approved in many countries since 2007. Generic versions were registered in 2020. Structure and properties Dasatinib (C22H26ClN7O2S, Mr = 488.0 g/mol) exists as a white powder that is insoluble in water. It is an aminopyrimidine derivative. Effects Dasatinib (ATC L01XE06) … Dasatinib
Products Empagliflozin is commercially available in the form of film-coated tablets. It was approved in the EU, the United States, and many countries in 2014 (Jardiance). Empagliflozin is also combined fixed with metformin (Jardiance Met) as well as with linagliptin (Glyxambi). Trijardy XR is a fixed combination of empagliflozin, linagliptin, and metformin. Structure and properties … Empagliflozin
Products Cabazitaxel is released as a concentrate for the preparation of an infusion solution. It has been approved in many countries since 2011 (Jevtana). Structure and properties Cabazitaxel (C45H57NO14, Mr = 835.9 g/mol) is a taxane semisynthetically derived from a constituent of yew needles. It is structurally closely related to docetaxel, which is itself a … Cabazitaxel
Products In many countries, the special extract Ze 339 from the leaves of the common butterbur ( L., Asteraceae) has been approved for the treatment of hay fever since 2003 (Tesalin, Zeller Heuschnupfen). Since 2018, the drug is also available without a doctor’s prescription. The list reclassification took place in September 2017. Ingredients Petasins, esterified … Butterbur against Hay Fever
Products Nilotinib is commercially available in capsule form (Tasigna). It has been approved in many countries since 2007. Structure and properties Nilotinib (C28H22F3N7O, Mr = 529.5 g/mol) is present in the drug product as nilotinib hydrochloride monohydrate, a white to slightly yellowish or greenish-yellow powder. The aminopyrimidine is structurally closely related to its precursor imatinib … Nilotinib
Products Ivacaftor was approved by the FDA and EMA in 2012 and by Swissmedic in 2014 in film-coated tablet form (Kalydeco). Also available is a fixed combination with lumacaftor (Orkambi). In 2016, a granule was also approved. In 2018, the combination with tezacaftor was approved in the US and EU (Symdeko, Symkevi). In 2020, a … Ivacaftor
Products Topotecan is commercially available in capsule form and as a lyophilizate (Hycamtin, generic). It has been approved in many countries since 1996. Structure and properties Topotecan (C23H23N3O5, Mr = 421.4 g/mol) is present in the drug as topotecan hydrochloride. It is a semisynthetic derivative of camptothecin, a plant alkaloid derived from the tree. Effects … Topotecan
Products Trabectedin is commercially available as a powder for the preparation of an infusion solution concentrate (Yondelis). It has been approved in many countries since 2009. Structure and properties Trabectedin (C39H43N3O11S, Mr = 761.8 g/mol) is a tetrahydroisoquinoline alkaloid from sea squirt , a marine animal belonging to the tunicates. The active ingredient is produced … Trabectedin
Products Clopidogrel is commercially available in tablet form (Plavix, generics). It has been approved in the United States since 1997 and in many countries and the EU since 1998. Clopidogrel is also combined with acetylsalicylic acid fixed (DuoPlavin). Structure and properties Clopidogrel (C16H16ClNO2S, Mr = 321.82 g/mol) is a thienopyridine derivative and a prodrug. It … Clopidogrel: Drug Effects, Side Effects, Dosage and Uses
Products Isavuconazonium sulfate is commercially available as a powder for a concentrate for the preparation of an infusion solution and in capsule form (Cresemba). It was approved in the US and EU in 2015 and in many countries in 2017. Structure and properties Isavuconazonium sulfate (C35H35F2N8O5S+ – HSO4– Mr = 814.8 g/mol) is a prodrug … Isavuconazonium Sulfate
