Products Amoxicillin is commercially available in the form of tablets, film-coated tablets, dispersible tablets, as powder or granules for the preparation of a suspension, as an infusion and injection preparation, and as a veterinary drug. In addition to the original Clamoxyl, numerous generics are available today. Amoxicillin was launched in 1972 and has been approved … Amoxicillin (Amoxil)
Products Cefamandol is commercially available as an injectable (Mandokef). It has been approved in many countries since 1978. Structure and properties Cefamandol (C18H18N6O5S2, Mr = 462.5 g/mol) is present in drugs as cefamandolafate, a white powder that is readily soluble in water. Effects Cefamandol (ATC J01DA07) has bactericidal properties. The effects are due to inhibition … Cefamandol
Products Cefaclor is commercially available as sustained-release film-coated tablets and as a suspension (Ceclor). It has been approved in many countries since 1978. Structure and properties Cefaclor monohydrate (C15H14ClN3O4S – H2O, Mr = 385.8) is a white to pale yellow powder that is sparingly soluble in water. It is a semisynthetic antibiotic and has structural … Cefaclor
Definition and mechanisms A pharmacokinetic booster is an agent that improves the pharmacokinetic properties of another agent. It is a desirable drug interaction It can exert its effects at different levels (ADME): Absorption (uptake into the body). Distribution (distribution) Metabolism and first-pass metabolism (metabolization). Elimination (excretion) Pharmacokinetic enhancers can increase absorption, increase distribution to an … Pharmacokinetic Booster
Products Valaciclovir is commercially available in the form of film-coated tablets (Valtrex, generic). It has been approved in many countries since 1995. Structure and properties Valaciclovir (C13H20N6O4, Mr = 324.3 g/mol) is the ester of the natural amino acid valine and the antiviral drug aciclovir. It is present in drugs as valaciclovir hydrochloride, a white … Valaciclovir
Products Dapsone is approved in Germany in tablet form (Dapsone-Fatol). In the USA, it is additionally on the market as a gel for the treatment of acne (Aczone). No preparations are currently registered in many countries. Structure and properties Dapsone or 4,4′-diaminodiphenylsulfone (C12H12N2O2S, Mr = 248.3 g/mol) is a sulfone and aniline derivative with structural … Dapsone
Effects Carbapenems (ATC J01DH) are bactericidal against aerobic and anaerobic Gram-positive and Gram-negative pathogens. Effects are based on binding to penicillin-binding proteins (PBP) and inhibition of bacterial cell wall synthesis, resulting in bacterial dissolution and death. Imipenem, the first representative of the drug group, is degraded by the renal enzyme dehydropeptidase-I (DHP-I). It is therefore … Carbapeneme
Products Penicillins are commercially available today in the form of film-coated tablets, capsules, as solutions for injection and infusion, as powders for preparing an oral suspension, and as syrups, among others. Penicillin was discovered in September 1928 at St. Mary’s Hospital in London by Alexander Fleming. He was working with staphylococcal cultures in Petri dishes. … Penicillins
Products Oseltamivir is commercially available as capsules and as a powder for oral suspension (Tamiflu). It has been approved in many countries since 1999. Generics were first registered in the EU in 2014 (ebilfumin) and in many countries in 2018. Structure and properties Oseltamivir (C16H28N2O4, Mr = 312.4 g/mol) is present in drugs as oseltamivir … Oseltamivir
Products Gliclazide has been commercially available in sustained-release tablet form and approved in many countries since 1978. The sustained-release dosage forms entered the market in 2001. In addition to the original Diamicron MR, sustained-release generics have been available since 2008. Sales of the non-retarded Diamicron 80 mg were discontinued in 2012. Structure and properties Gliclazide … Gliclazide
Products Methotrexate is commercially available as a solution for parenteral use and in tablet form. See also under methotrexate prefilled syringe (low-dose). Structure and properties Methotrexate (C20H22N8O5, Mr = 454.44 g/mol) is a dicarboxylic acid that exists as a yellow to orange crystalline powder that is virtually insoluble in water. Methotrexate was developed as a … Methotrexate: Drug Effects, Side Effects, Dosage and Uses
Products Prefilled methotrexate syringes have been approved in many countries since 2005 (Metoject, generic). They contain between 7.5 to 30 mg of active ingredient, in increments of 2.5 mg. The dose is much lower than for chemotherapy (“low-dose methotrexate“). The syringes are stored at room temperature between 15 to 25 °C and protected from light. … Methotrexate Ready-To-Use Syringe
