Products Meropenem is commercially available as a powder for solution for injection/infusion (Meronem, generic). It has been approved in many countries since 1995. The antibiotic is also combined with the beta-lactamase inhibitor vaborbactam. Structure and properties Meropenem (C17H25N3O5S, Mr = 383.5 g/mol) is present in drugs as meropenem trihydrate, a white to slightly yellowish crystalline … Meropenem
Products Cidofovir was initially marketed in many countries as an infusion concentrate under the brand name Vistide (Gilead). It was approved in many countries in 1997 and had not been available since 2014. In 2017, a concentrate for the preparation of an infusion solution was approved (Sidovis). Structure and properties Cidofovir (C8H14N3O6P, Mr = 279.2 … Cidofovir
Symptoms Gout is an inflammatory disease of the joints that manifests acutely in attacks of severe pain that worsens with pressure, touch, and movement. The joints are swollen with inflammation, and the skin is red and warm. Fever is observed. Gout often begins in the lower extremities and at the metatarsophalangeal joint (podagra). Urat crystals … Gout Causes and Treatment
Probenecid is a second-line drug for hyperuricemia and gout. It inhibits the URAT1 exchanger in the kidney, increasing the release of urea into the urine while decreasing the excretion of organic anions. Probenecid interacts with numerous other drugs. What is probenecid? Because the drug stimulates the body to excrete uric acid, probenecid belongs to the … Probenecid: Effects, Uses & Risks
Products Nonsteroidal anti-inflammatory drugs (NSAIDs) are available in numerous dosage forms. These include film-coated tablets, tablets, sustained-release tablets, oral suspensions, oral granules, suppositories, NSAID eye drops, lozenges, emulsifying gels, and creams (selection). The first active ingredient from this group was salicylic acid, which was used medicinally in the 19th century in the form of the … NSAID
Products Lorazepam is commercially available as tablets, meltable tablets, and a solution for injection. In addition to the original Temesta, generics and a combination product with the sedative antihistamine diphenhydramine are also available (Somnium). Lorazepam has been approved in many countries since 1973. Structure and properties Lorazepam (C15H10Cl2N2O2, Mr = 321.2 g/mol) is a white … Lorazepam
Products Nitrofurantoin is commercially available in many countries in the form of 100 mg sustained-release capsules (Furadantin retard, Uvamin retard). It has been used medicinally since the early 1950s. Structure and properties Nitrofurantoin (C8H6N4O, Mr = 238.2 g/mol) exists as a yellow crystalline powder that is very sparingly soluble in water. It is a nitrated … Nitrofurantoin
Products Famciclovir is commercially available in the form of film-coated tablets (Famvir). It has been approved in many countries since 1995. Structure and properties Famciclovir (C14H19N5O4, Mr = 321.3 g/mol) is the orally available prodrug of penciclovir, which is itself a prodrug of penciclovir triphosphate. Famciclovir exists as a white to yellowish powder that is … Famciclovir
Products Famotidine is not commercially available in many countries. In Germany and other countries, it is available in the form of film-coated tablets. Structure and properties Famotidine (C8H15N7O2S3, Mr = 337.4 g/mol) exists as a white to yellowish-white crystalline powder or as crystals and is very sparingly soluble in water. It is a thiazole derivative … Famotidine
Structure and properties Doripenem (C15H24N4O6S2, Mr = 420.5 g/mol) exists as doripenem monohydrate, a white to slightly yellow crystalline powder. It bears a 1-β-methyl group that protects it from degradation by dehydropeptidase I. Effects Doripenem (ATC J01DH04) is bactericidal against numerous aerobic and anaerobic Gram-positive and Gram-negative bacteria. Its effects are based on inhibition of … Doripenem
Products Probenecid is commercially available in tablet form (Santuril). Santuril has been approved in many countries since 2005. Structure and properties Probenecid (C13H19NO4S, Mr = 285.4 g/mol) is a white crystalline powder that is practically insoluble in water. Effects Probenecid (ATC M04AB01) inhibits tubular reabsorption of uric acid and secretion of organic anions. It thus … Probenecid
Indication Gout Active ingredients Benzbromarone (Desuric, off label). Lesinurad (Zurampic) Probenecid (Santuril) Sulfinpyrazone (out of commerce)
