Spinal Muscular Atrophy: Drug Therapy

Therapy goals Alleviation of symptomatology and discomfort Slowing of the progression Healing Therapy recommendations Nusinersen (Spinraza; drug from the antisense oligonucleotide class; available in Germany since July 2017): This is a single-stranded nucleic acid that binds to the complementary intron (noncoding region of a pre-RNA transcript) 7 of SMN2 pre-mRNA (mRNA subject to processing), preventing … Spinal Muscular Atrophy: Drug Therapy

Deformities of the Hip: Diagnostic Tests

Obligatory medical device diagnostics. Postpartum hip ultrasonography/ultrasound method according to Graf (ultrasound hip screening: screening U3 (4th-6th week of life); newborns with risk factors early screening between the 3rd and 10th day of life (U2)) – Specificity (probability that actually healthy persons who do not suffer from the disease in question are also detected as … Deformities of the Hip: Diagnostic Tests

Psoriatic Arthritis: Classification

The CASPAR criteria are used to classify psoriatic arthritis: Classification Criteria for the Diagnosis of Psoriatic Arthritis. Psoriatic arthritis is considered diagnosed when there is inflammatory disease of joints, the spine, or the entheses (tendon attachments or sheaths) and three items also arise from the criteria listed below: Criterion Points Psoriasis currently present 2 Or … Psoriatic Arthritis: Classification

Progesterone: Effects

Progesterone is a hormone from the group of progestins. It is produced in the ovaries in the corpus luteum (in the corpus luteum) and increases during the luteal phase (corpus luteum phase) – on the 5th-8th day after ovulation (ovulation) is the maximum serum level – and during pregnancy. Progesterone is responsible for nidation (implantation … Progesterone: Effects

Hepatitis C: Therapy

General measures Partner management, i.e., infected partners, if any, must be located and treated (contacts must be traced back to the estimated time of infection). Observance of the general hygiene measures! Genital hygiene Once a day, the genital area should be washed with a pH-neutral care product. Washing several times a day with soap, intimate … Hepatitis C: Therapy

Penile Curvature (Penile Deviation): Complications

The following are the most important diseases or complications that may be contributed to by penile deviation (penile curvature): Endocrine, nutritional, and metabolic diseases (E00-E90). Hypogonadism (more common in men with induratio penis plastica). Circulatory system (I00-I99) Thrombophlebitis (superficial phlebitis) or thrombosis of a vein running along the back of the vein. Genitourinary system (kidneys, … Penile Curvature (Penile Deviation): Complications

Ovary and Fallopian Tube Inflammation (Adnexitis): Surgical Therapy

1st order Laparoscopy (laparoscopy): this may assist in early improvement of severe disease by loosening adhesions (adhesions) and draining pelvic abscesses; ultrasound-guided aspiration (suction) of pelvic fluid collections, if necessary, as a less invasive procedure Plastic surgical reconstruction for adhesions (adhesions) in the area of the adnexa (due tochronic salpingitis / oophoritis), for example, by … Ovary and Fallopian Tube Inflammation (Adnexitis): Surgical Therapy

Uterine Fibroids (Uterus Myomatosus, Leiomyomas): Drug Therapy

Therapeutic Objective Improvement of symptoms by drug control of bleeding disorders (hypermenorrhea, menometrorrhagia) or preoperative reduction of fibroids. Therapy recommendations Estrogen-progestin single-phase preparations, progestin preparations, intrauterine device with progestin (levonorgestrel) for drug control of bleeding disorders. Ulipristal (ulipristal acetate; progesterone receptor modulator) for preoperative (“before surgery”) reduction of fibroids. See also under “Further therapy“. Note: … Uterine Fibroids (Uterus Myomatosus, Leiomyomas): Drug Therapy

Protein Electrophoresis in Urine

Electrophoresis refers to a laboratory test in which electrically charged particles of blood migrate in an electric field.The speed of this migration depends, among other things, on the ionic charge of the particles, the field strength, and the radius of the particles. One can distinguish the different forms of electrophoresis: Protein electrophoresis in blood serum … Protein Electrophoresis in Urine

Sarcoidosis: Diagnostic Tests

Obligatory medical device diagnostics. X-ray of the thorax (radiographic thorax/chest), in two planes. Computed tomography of the thorax/chest (thoracic CT). Optional medical device diagnostics – depending on the results of the medical history, physical examination, laboratory diagnostics and mandatory medical device diagnostics – for differential diagnostic clarification. Pulmonary function testing-serial spirometry, particularly forced vital capacity … Sarcoidosis: Diagnostic Tests