Products Cefepime is commercially available as a powder for solution for injection or infusion (generic). It has been approved in many countries since 2007. Structure and properties Cefepime (C19H24N6O5S2, Mr = 480.6 g/mol) is present in drugs as cefepim dihydrochloride monohydrate, a white to yellowish powder that is readily soluble in water. Effects Cefepime (ATC … Cefepime
Products Cefixime was commercially available in tablet form (Cephoral). It had been approved in many countries since 1992. Structure and properties Cefixime (C16H15N5O7S2, Mr = 453.4 g/mol) is a white powder that is sparingly soluble in water. It is a semisynthetic cephalosporin. In medicinal products, it is anhydrous. Effects Cefixime (ATC J01DD08) is bactericidal against … Cefixime
Products Injectables containing cefotaxime are no longer available in many countries Claforan is off the market. It was approved in 1981. Structure and properties Cefotaxime (C16H17N5O7S2, Mr = 455.5 g/mol) Effects Cefotaxime (ATC J01DA10) has bactericidal properties by inhibiting cell wall synthesis. Indications Bacterial infectious diseases
Products Cefpodoxime is commercially available as film-coated tablets and as granules for preparation of a suspension (Podomexef, generics). It has been approved in many countries since 1991. Structure and properties Cefpodoxime (C15H17N5O6S2, Mr = 427.5 g/mol) is present in drugs as cefpodoxime proxetil. It is an ester prodrug and is rapidly converted to cefpodoxime in … Cefpodoxime
Products Cefprozil was commercially available as film-coated tablets and as a suspension (Procef). It was approved in many countries in 1995 and is currently no longer available. Structure and properties Cefprozil (C18H19N3O5S, Mr = 389.4 g/mol) is present in drugs as cefprozil monohydrate, a white to yellowish powder that is sparingly soluble in water. Effects … Cefprozil
Products Ceftarolinefosamil is commercially available as a powder for the preparation of a concentrate for an infusion solution (Zinforo). It has been approved in many countries since 2013. Structure and properties Ceftarolinefosamil (C22H21N8O8PS4, Mr = 684.7 g/mol) is present in drugs as ceftarolinefosamil monoacetate monohydrate, a yellowish-white powder. Ceftarolinefosamil is a prodrug that is enzymatically … Ceftarolinefosamil
Products Cephalosporins are commercially available in the form of film-coated tablets, oral suspensions, granules, and injection and infusion preparations, among others. The basis for the discovery of cephalosporins was the isolation of the mold by the physician Giuseppe Brotzu. He found the fungus in wastewater from Cagliari in Sardinia in 1945. At the University of … Cephalosporins
Products Ceftobiprole was approved in many countries in 2009 as a powder for a concentrate for the preparation of an infusion solution (Zevtera). Structure and properties Ceftobiprole (C20H22N8O6S2, Mr = 534.6 g/mol) is present in the drug in the form of the prodrug ceftobiprole medocaril and as a sodium salt. The prodrug is converted to … Ceftobiprole
Products Ceftriaxone is commercially available as a powder and solvent for the preparation of a solution for injection (Rocephin, generics). It has been approved in many countries since 1982 and is also used in fixed combination with lidocaine. Structure and properties Ceftriaxone (C18H18N8O7S3, Mr = 554.6 g/mol) is present in drugs as ceftriaxone disodium (3.5 … Ceftriaxone
Products Cefuroxime is commercially available as film-coated tablets, powder for suspension, and injectable (Zinat, Zinacef, Aprokam, generics). It has been approved in many countries since 1988. Structure and properties Cefuroxime (C16H15N4NaO8S, Mr = 446.4 g/mol) is present in peroral drugs in the form of the acetoxyethyl ester prodrug cefuroxime axetil, a white powder that is … Cefuroxime
Products Piperacillin is commercially available as an injectable (tazobac + tazobactam, generics). It has been approved in many countries since 1992. Structure and properties Piperacillin (C23H27N5O7S, Mr = 517.6 g/mol) is present in drugs as piperacillin sodium, a white crystalline powder that is readily soluble in water. Tazobactam (C10H12N4O5S, Mr = 300.3 g/mol) also exists … Piperacillin
Products Ceftazidime is commercially available as a solution for injection and infusion (Fortam, generic). It has been approved in many countries since 1984. In 2019, a fixed-dose combination with the beta-lactamase inhibitor avibactam was registered; see Avibactam (Zavicefta). Structure and properties Ceftazidime (C22H22N6O7S2 – 5 H2O, Mr = 637 g/mol) is a white crystalline powder … Ceftazidime
