Products Chlortalidone is commercially available in tablet form (combination products). It has been approved in many countries since 1967. This article refers to the monopreparations. Hygroton (Novartis) was discontinued in many countries in 2014. Structure and properties Chlortalidone (C14H11ClN2O4S, Mr = 338.77 g/mol) is a racemate. It exists as a white to yellowish white powder … Chlortalidone
Products Metolazone is commercially available in tablet form as a generic product (Metolazone Galepharm). The original Zaroxolyn is no longer available. Structure and properties Metolazone (C16H16ClN3O3S, Mr = 365.8 g/mol) is a quinazoline sulfonamide that is sparingly soluble in water. It is structurally related to the thiazides. Effects Metolazone (ATC C03BA08) has diuretic and thiazide-like … Metolazone
Products Indapamide is commercially available as tablets and capsules alone in sustained-release formulations (Fludex SR, generic) and in combination with the ACE inhibitor perindopril (Coversum N Combi, generic). A fixed combination of perindopril, indapamide, and amlodipine is also available (Coveram plus). Indapamide was developed in the 1970s and has been approved in many countries since … Indapamide
Products Loop diuretics are commercially available as tablets, sustained-release capsules, and injection and infusion preparations. Torasemide and furosemide are the most commonly used in many countries today. Structure and properties Available loop diuretics are usually sulfonamide or sulfonylurea derivatives. Representatives without a sulfonamide structure also exist, for example, the phenoxyacetic acid derivative etacrynic acid. Effects … Loop Diuretics
Products Benzthiazide is no longer commercially available in many countries. It was formerly included in combination with triamterene in Dyrenium compositum. Structure and properties Benzthiazide (C15H14ClN3O4S3, Mr = 431.9 g/mol) Effects Benzthiazide has diuretic properties. Indications Edema Arterial hypertension
Products Butizide was marketed exclusively in combination with spironolactone in the form of film-coated tablets (Aldozone). It had been approved in many countries since 1968. Structure and properties Buticide (C11H16ClN3O4S2, Mr = 353.8 g/mol) Effects Buticide (ATC C03EA14) has diuretic properties. Indications In combination with spironolactone: Heart failure Liver cirrhosis with ascites and/or edema. Nephrotic … Buticide
Products Bumetanide was commercially available in tablet form (Burinex, off label). It was approved in many countries in 1974. Structure and properties Bumetanide (C17H20N2O5S, Mr = 364.4 g/mol) is a white crystalline powder that is practically insoluble in water. Effects Bumetanide (ATC C03CA02) is diuretic with rapid onset and short duration of action. Indications Oedema … Bumetanide
