Products Oxybutynin is commercially available in tablet form and as a transdermal patch (Ditropan, Kentera). It has been approved in many countries since 1988, and the transdermal patch has been available since 2007. Extemporaneous formulations are also produced; see Intravesical oxybutynin solution (for use in the urinary bladder). Other dosage forms have been released in … Oxybutynin
Products Lumateperone was approved in the United States in 2019 in capsule form (Caplyta). Structure and properties Lumateperone (C24H28FN3O, Mr = 393.5 g/mol) is present in the drug as lumate perontosylate. Like haloperidol (Haldol), for example, it belongs to the butyrophenone group. Effects Lumateperone has antipsychotic and antidepressant properties. Effects are attributed to antagonism at … Lumateperon
Products Lurasidone is commercially available in the form of film-coated tablets (Latuda). It has been approved in many countries since 2013. In the United States, it was registered as early as 2010. Structure and properties Lurasidone (C28H36N4O2S, Mr = 492.7 g/mol) belongs to the benzoisothiazoles. It exists as a white powder that is sparingly soluble … Lurasidon
Products Terazosin is commercially available in tablet form (Hytrin BPH) and has been approved in many countries since 1994. It is no longer registered for the treatment of high blood pressure in many countries (formerly Hytrin), but the indication still exists in other countries. Structure and properties Terazosin (C19H25N5O4, Mr = 387.4 g/mol) is a … Terazosin
Products Alpha blockers are available in many countries in the form of tablets, sustained-release tablets, capsules, and sustained-release capsules. The most commonly prescribed today is tamsulosin (Pradif T, generic). Alpha blocker is short for alpha1-adrenoreceptor antagonist. Structure and properties The first alpha blockers-alfuzosin, doxazosin, and terazosin-were developed as derivatives of quinazoline: Effects Alpha blockers (ATC … Alpha Blocker
Products Naloxone nasal spray was approved in the United States in 2015 (Narcan), in the EU in 2017, and in many countries in 2018 (Nyxoid). Each nasal spray contains only one dose and can be used only once. Structure and properties Naloxone (C19H21NO4, Mr = 327.37 g/mol) is a semisynthetic derivative of morphine. It is … Naloxone Nasal Spray
Products Lifitegrast was approved in the United States in 2016 and in many countries in December 2018 as single-dose eye drops (Xiidra, pronounced Saidra in English). Structure and properties Lifitegrast (C29H24Cl2N2O7S, Mr = 615.5 g/mol) is a tetrahydroisoquinoline derivative. It exists as a white powder that is soluble in water. Effects Lifitegrast (ATC S01XA25) has … Lifitegrast
Products Clascoterone was approved as a cream in the United States in 2020 (Winlevi). Structure and properties Clascoterone (C24H34O5, Mr = 402.5 g/mol) corresponds to the steroid cortexolone-17α-propionate. It exists as a white powder that is practically insoluble in water. Effects Clascoterone has antiandrogenic properties. The effects are due to antagonism at androgen receptors. Androgens … Clascoteron
Products Clemastine is commercially available in tablet form and as a solution for injection (Tavegyl). It has been approved in many countries since 1967. Tavegyl gel has been off the market since 2010 because of low demand. It can be replaced, for example, by a dimetindene maleate gel (Fenistil). Structure and properties Clemastine (C21H26ClNO, Mr … Clemastine
