Products Trastuzumab is commercially available as a lyophilizate for preparation of an infusion concentrate (Herceptin, biosimilars). It has been approved in many countries since 1999 (US: 1998, EU: 2000). In 2016, an additional solution for subcutaneous injection for breast cancer therapy was released in many countries (Herceptin subcutaneous). It was available earlier in other countries. … Trastuzumab
Structure and properties Daunorubicin (C27H29NO10, Mr = 527.5 g/mol) Effects Daunorubicin (ATC L01DB02) is a cytotoxic anthracycline antibiotic. It is isolated from cultures of various Streptomyces strains. By intercalation into DNA, it inhibits topoisomerase II and thereby nucleic acid and protein synthesis and cell division. Indications Leukemia Hodgkin’s disease Neuroblastoma
Products Trabectedin is commercially available as a powder for the preparation of an infusion solution concentrate (Yondelis). It has been approved in many countries since 2009. Structure and properties Trabectedin (C39H43N3O11S, Mr = 761.8 g/mol) is a tetrahydroisoquinoline alkaloid from sea squirt , a marine animal belonging to the tunicates. The active ingredient is produced … Trabectedin
Daunorubicin is a drug in the cytostatic and anthracycline drug class. The drug is used as a cytostatic agent. What is daunorubicin? Daunorubicin is available by prescription and is used to treat a variety of cancers. For this purpose, the drug is infused intravenously. Daunorubicin is both a glycoside and an antibiotic. It comes from … Daunorubicin: Effects, Uses & Risks
Products Epirubicin is commercially available as a concentrate for injection/instillation (farmorubicin, generics). It has been approved in many countries since 1993. Structure and properties Epirubicin (C27H29NO11, Mr = 543.5 g/mol) is structurally closely related to doxorubicin. Effects Epirubicin (ATC L01DB03) is antineoplastic. It is an anthracycline antibiotic, rapidly penetrates the cell, binds to DNA, and … Epirubicin
Products Mitoxantrone is commercially available as an infusion/injection solution (Novantrone, generic). It has been approved in many countries since 1985. Structure and properties Mitoxantrone (C22H28N4O6, Mr = 444.5 g/mol) Effects Mitoxantrone (ATC L01DB07) has cytotoxic and immunosuppressive properties. The effects are due to inhibition of topoisomerase II and intercalation of DNA. Indications Carcinomas, lymphomas, leukemia … Mitoxantrone
Products Idarubicin is commercially available in capsule form and as a solution for injection (Zavedos, generics). It has been approved in many countries since 1992. Structure and properties Idarubicin (C26H27NO9, Mr = 497.5 g/mol) Effects Idarubicin (ATC L01DB06) is a cytotoxic anthracycline antibiotic. It inhibits topoisomerase II by intercalation into DNA, thereby inhibiting nucleic acid … Idarubicin
Products Doxorubicin is commercially available as an injectable (Adriblastin, generic). It has been approved in many countries since 1989. Caelyx is a pegylated and liposomal formulation of the drug and was registered in 1997. Myocet is a liposomal and nonpegylated formulation. Structure and properties Doxorubicin (C27H29NO11, Mr = 543.5 g/mol) is structurally closely related to … Doxorubicin
Cytarabine is a cytostatic drug and is used primarily to treat acute myeloid leukemia. In this indication, it is among the most commonly used cytostatic drugs. It is also used in acute lymphoblastic leukemia (also known as acute lymphocytic leukemia), myelodysplastic syndrome and non-Hodgkin’s lymphoma. Cytarabine also has a virostatic effect, although it is not … Cytarabine: Effects, Uses & Risks
Dexrazoxane is a drug used in human medicine. It is used as part of chemotherapy to treat various forms of cancer. For these purposes, dexrazoxane is usually administered with anthracyclines, which reduces the cytotoxic effect of dexrazoxane. Due to its pharmacological properties as well as its specific field of application, dexrazoxane belongs to the cytostatic … Dexrazoxane: Effects, Usage & Risks
Renal cell carcinoma is a malignant tumor that originates from the tubular cells of the kidneys. The majority of all kidney tumors are renal cell carcinomas. What is renal cell carcinoma? About three percent of all malignancies in adults are renal carcinomas. Nine out of every 100,000 people develop renal cell carcinoma each year. Most … Renal Cell Carcinoma: Causes, Symptoms & Treatment
Anthracyclines are a group of compounds isolated from bacteria that are used as cytostatic agents. Indications for the resulting agents, mitoxantrone, epirubicin, idarubicin, and daunorubicin, are leukemias and other carcinogenic diseases. Via processes of intercalation, the drugs target tumor cells and prevent their division. What are anthracyclines? Anthracyclines are a group of antibiotically active compounds. … Anthracyclines: Effects, Uses & Risks
