Products and ingredients Inhalation solution B is not commercially available as a finished drug in many countries and must be prescribed by a physician as an extemporaneous prescription and prepared in a pharmacy. In practice, different manufacturing prescriptions are used with the pure substances or the solutions. Dospir and Ipramol have a similar composition, but … Inhalation Solution B
Products Lofexidine was approved in the United States in 2018 in film-coated tablet form (Lucemyra). In the United Kingdom, the agent was approved for the treatment of opioid withdrawal back in the early 1990s (UK: BritLofex). Structure and properties Lofexidine (C11H12Cl2N2O, Mr = 259.1 g/mol) is present in the drug as lofexidine hydrochloride, a white … Lofexidine
Products Lisdexamphetamine (LDX) was approved in many countries in March 2014 in capsule form (Elvanse). It has been available in the United States since 2007 (Vyvanse). The dosage form is non-retarded, unlike other ADHD medications. Continuous release is achieved with the conversion of the prodrug. Lisdexamphetamine is legally classified as a narcotic and therefore requires … Lisdexamphetamine
Products Bextra film-coated tablets are no longer on the market in many countries. Approval was withdrawn in April 2005 because rare severe skin reactions had occurred during treatment (see below). Structure and properties Valdecoxib (C16H14N2O3S, Mr = 314.4 g/mol) is a phenylisoxazole and a benzenesulfonamide derivative. It has a V-shaped structure with which it binds … Valdecoxib
Products Felodipine is commercially available in the form of sustained-release tablets. In addition to the original Plendil, generic versions are also available. It has been approved in many countries since 1988. Structure and properties Felodipine (C18H19Cl2NO4, Mr = 384.3 g/mol) is a dihydropyridine. It exists as a white to pale yellow crystalline powder that is … Felodipine
Products Fenbendazole is commercially available as granules, paste, powder, bolus, suspension, and tablets, among others. It has been approved in many countries since 1976. Structure and properties Fenbendazole (C15H13N3O2S, Mr = 299.3 g/mol) is a benzimidazole derivative. It exists as a white powder that is practically insoluble in water. Effects Fenbendazole (ATCvet QP52AC13) has antihelminthic … Fenbendazole
Products Ketazolam is commercially available in capsule form (Solatran). It has been approved in many countries since 1980. Structure and properties Ketazolam (C20H17ClN2O3, Mr = 368.8 g/mol) structurally belongs to the 1,4-benzodiazepines. Effects Ketazolam (ATC N05BA10) has antianxiety, depressant, muscle relaxant, and anticonvulsant properties. The effects are due to binding to GABA-A receptors and enhancement … Ketazolam
Products To date, hydrocortisone acetate is the only glucocorticoid approved for self-medication in many countries and is available without a doctor’s prescription. A cream (Dermacalm with dexpanthenol) and a hydrocream (Sanadermil) are available. Hydrocortisone was the first dermocorticoid and was introduced in the 1950s. Structure and properties Hydrocortisone acetate (C23H32O6, Mr = 404.5 g/mol) is … Hydrocortisone Acetate
Products Penicillins are commercially available today in the form of film-coated tablets, capsules, as solutions for injection and infusion, as powders for preparing an oral suspension, and as syrups, among others. Penicillin was discovered in September 1928 at St. Mary’s Hospital in London by Alexander Fleming. He was working with staphylococcal cultures in Petri dishes. … Penicillins
Products Orexin receptor antagonists are commercially available in tablet form. The first agent in this group to be approved in the United States was suvorexant (Belsomra) in 2014. Lemborexant (Dayvigo) followed in 2019. Structure and properties Orexin receptor antagonists are characterized by a central ring structure to which heterocycles are attached on both sides. Effects … Orexin Receptor Antagonists
Products Nilotinib is commercially available in capsule form (Tasigna). It has been approved in many countries since 2007. Structure and properties Nilotinib (C28H22F3N7O, Mr = 529.5 g/mol) is present in the drug product as nilotinib hydrochloride monohydrate, a white to slightly yellowish or greenish-yellow powder. The aminopyrimidine is structurally closely related to its precursor imatinib … Nilotinib
Active substances (selection) Gadobenic acid Gadobutrol Gadodiamide Gadofosveset Gadoteric acid Gadotenic acid Gadoversetamide Iobitridol Iohexol Iomeprol Iopamidol Iopromide Ioversol Mangafodipir
