Products Ergocalciferol (vitamin D2, calciferol) is commercially available in many countries, including as a dietary supplement in the form of capsules. Vitamin D2 is much less commonly used than cholecalciferol (vitamin D3) in many countries. In the United States, on the other hand, ergocalciferol is more traditionally used. Structure and properties Ergocalciferol (C28H44O, Mr = … Ergocalciferol (Vitamin D2)
Products Axitinib was approved in many countries in 2012 in film-coated tablet form (Inlyta). Structure and properties Axitinib (C22H18N4OS, Mr = 386.5 g/mol) is a benzamide and benzindazole derivative. It exists as a white to slightly yellow powder. Effects Axitinib (ATC L01XE17) has antitumor properties. The effects are due to inhibition of VEGFR-1, -2, and … Axitinib
Products Dihydroergocriptine is no longer registered in many countries. Cripar is out of commerce. Effects Dihydroergocriptine (ATC N04BC03) is dopaminergic and acts selectively on D2 receptors. It has no activity on serotoninergic or adrenergic receptors. Indications Parkinson’s disease Early stages of Parkinson’s disease, as monotherapy or in combination with an L-dopa preparation. Interval treatment of … Dihydroergocriptine
Products Dihydropyridines are commercially available in many countries in the form of film-coated tablets, sustained-release tablets, capsules, and injectables. Nifedipine from Bayer (Adalat) was the first active ingredient from this group to enter the market in the mid-1970s. Today, amlodipine (Norvasc, generics) is most commonly prescribed. Structure and properties The name 1,4-dihydropyridines is derived from … Dihydropyridine
Products Risankizumab was approved in the United States and in many countries in 2019 as a solution for injection (Skyrizi). Structure and properties Risankizumab is a humanized IgG1 monoclonal antibody produced by biotechnological methods. Effects Risankizumab (ATC L04AC) has selective immunosuppressive and anti-inflammatory properties. The antibody binds to the p19 subunit of human interleukin-23 (IL-23), … Risankizumab
Products Ritonavir is commercially available as a monopreparation in the form of film-coated tablets (Norvir). It was approved in many countries, in the United States and in the EU in 1996, and is also used as a pharmacokinetic booster in combination with antiviral agents (eg, lopinavir). Norvir syrup is no longer marketed in many countries. … Ritonavir
Products Rivaroxaban is commercially available in the form of film-coated tablets (Xarelto, Xarelto vascular). It was approved in 2008 as the first agent in the direct factor Xa inhibitor group. Low-dose Xarelto vascular, 2.5 mg, was registered in many countries in 2019. Structure and properties Rivaroxaban (C19H18ClN3O5S, Mr = 435.9 g/mol) is a pure -enantiomer … Rivaroxaban
Products Pyriproxifen is commercially available as a spot-on solution for cats. Medicines for dogs are approved in many countries but are not currently available. Structure and properties Pyriproxifen (C20H19NO3, Mr = 321.4 g/mol) is a pyridine derivative derived from fenoxycarb. Effects Pyriproxifen (ATCvet QP53AX23) inhibits the development of flea eggs and larvae for 3 months … Pyriproxifen
Products Quetiapine is commercially available in the form of film-coated tablets and sustained-release tablets (Seroquel / XR, generic, auto-generic). It has been approved in many countries since 1999. Generics of film-coated tablets entered the market in 2012, and generics of sustained-release tablets were first registered in 2013. Structure and properties Quetiapine (C21H25N3O2S, Mr = 383.5 … Quetiapine
Products Mitotane is commercially available in tablet form (Lysodren). It was approved in many countries in 2010. Structure and properties Mitotane or 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)benzene (C14H10Cl4, Mr = 320.041 g/mol) is a derivative of an insecticide. Effects Mitotane (ATC L01XX23) has a cytotoxic effect on the adrenal glands and may also cause adrenal inhibition without cell destruction. … Mitotan
Products Minocycline is commercially available in the form of film-coated tablets (Minocin). It has been approved in many countries since 1984. Minac capsules are out of commerce. Topical medicines are additionally available in some countries. Structure and properties Minocylcine (C23H27N3O7, Mr = 457.5 g/mol) is present in drugs as minocycline hydrochloride, a yellow, crystalline, hygroscopic … Minocycline
Products Minoxidil is commercially available as a solution and in some countries also as a foam (Regaine, generics, USA: Rogaine). It has been approved in many countries since 1987. The brand name plays on the English verb , which translates as to recover or get back. This article refers to external use. Tablets also exist … Minoxidil
