Products Antazoline is fixed combination with tetryzoline in the form of eye drops commercially available (Spersallerg, Spersallerg SDU). It has been approved in many countries since 1967. Structure and properties Antazoline (C17H19N3, Mr = 265.35 g/mol) is present in drugs as antazoline hydrochloride, a white crystalline powder that is sparingly soluble in water. It is … Antazoline: Antihistamine
Products Olodaterol was approved in many countries in 2014 as a solution for inhalation (Striverdi). In 2016, a fixed-dose combination with tiotropium bromide was also marketed (Spiolto). Both drugs are administered with the Respimat. Respimat The Respimat is a new inhalation device that releases a visible spray, or aerosol. The droplets are fine and move … Olodaterol
Products Lisinopril is commercially available in tablet form as a monopreparation (Zestril, generic) and as a fixed combination with hydrochlorothiazide (Zestoretic, generic). It has been approved in many countries since 1989. Structure and properties Lisinopril (C21H31N3O5, Mr = 405.49 g/mol) is present in drugs as lisinopril dihydrate, a white crystalline powder that is soluble in … Lisinopril: Drug Effects, Side Effects, Dosage and Uses
Products Liraglutide was approved in many countries in 2009 as a solution for injection in a prefilled pen (Victoza). In 2014, a fixed-dose combination with insulin degludec was released (Xultophy); see IDegLira. In 2016, Saxenda was registered for the treatment of overweight and obesity. Its related successor, semaglutide, unlike liraglutide, only needs to be injected … Liraglutide
Products Elbasvir was approved in many countries in 2016 as a fixed-dose combination with the protease inhibitor grazoprevir in film-coated tablet form (Zepatier). Structure and properties Elbasvir (C49H55N9O7, Mr = 882.0 g/mol) Effects Elbasvir (ATC J05AX68) has antiviral properties. The effects are due to binding to the viral protein NS5A (Non-Structural Protein 5A). Unlike other … Elbasvir
Products Vaborbactam was approved in the United States in 2017 as a fixed combination with the antibiotic meropenem (Vabomere, The Medicines Company). Meropenem belongs to the carbapenems and beta-lactam antibiotics group. Structure and properties Vaborbactam (C12H16BNO5S, Mr = 297.1 g/mol) is a cyclic boron compound and a boronic acid derivative. It is not a representative … Vaborbactam
Products Elexacaftor was approved in the United States in 2019 and in many countries in 2020 as a fixed-dose combination with tezacaftor and ivacaftor in film-coated tablet form (Trikafta). In the morning dose, all three active ingredients are included. In the evening dose, only ivacaftor. Structure and properties Elexacaftor (C26H34F3N7O4S, Mr = 597.7 g/mol) exists … Elexacaftor
Products Elvitegravir is commercially available as film-coated tablets in fixed combination with other antiretroviral agents and cobicistat (Stribild, successor: Genvoya). It has been approved in many countries since 2013. Stribild: elvitegravir, cobicistat, emtricitabine, and tenofovirdisoproxil. Genvoya: elvitegravir, cobicistat, emtricitabine and tenofoviralafenamide. Structure and properties Elvitegravir (C23H23ClFNO5, Mr = 447.9 g/mol) is a dihydroquinolone derivative. It … Elvitegravir
Products Darunavir is commercially available as film-coated tablets and as an oral suspension (Prezista). It has been approved in many countries since 2006. In 2016, a fixed-dose combination with cobicistat was approved (Rezolsta film-coated tablets). In 2018, generic versions of the tablets entered the market. Structure and properties Darunavir (C27H37N3O7S, Mr = 547.7 g/mol) is … Darunavir
Products No medicines containing clostebol are approved in many countries. Products available in some countries – for example, Italy and Brazil – include Trofodermin cream, a fixed combination with the antibiotic neomycin. Structure and properties Clostebol (C19H27ClO2, Mr = 322.9 g/mol) is a derivative of the male sex hormone testosterone chlorinated at position 4. Trofodermine … Clostebol
Products Dimethicone is commercially available in many countries as a drug in the form of capsules as a fixed combination with other active ingredients (Carboticon). It is also present in lice remedies, cosmetics and technical agents and has been registered since 1964. Structure and properties Dimethicone (C2H6OSi)n exists as a clear, colorless liquid of varying … Dimethicone
Products Calcipotriol is commercially available as a fixed combination with betamethasone dipropionate as a gel, ointment, and foam (Xamiol, Daivobet, Enstilar, generics). Structure and properties Calcipotriol (C27H40O3, Mr = 412.60 g/mol) is a synthetic derivative of natural vitamin D3 (cholecalciferol). It exists as a white crystalline powder. Effects Calcipotriol (ATC D05AX02) has antiproliferative, anti-inflammatory, and … Calcipotriol
