Products Canrenone is commercially available as an injectable (Soldactone). It has been approved in many countries since 1975. Structure and properties Canrenone (C22H28O3, Mr = 340.5 g/mol) is an active metabolite of spironolactone (aldactone) and, unlike the latter, is soluble in water. Canrenone is present in drugs as potassium canrenoate, the potassium salt of canrenoic … Canrenon
Products Capecitabine is commercially available in the form of film-coated tablets (Xeloda, generic). It has been approved in many countries since 1998. Structure and properties Capecitabine (C15H22FN3O6, Mr = 359.4 g/mol) is a prodrug and is converted to the cell-toxic 5-fluorouracil, the active drug, in a three-step process. Capecitabine exists as a white crystalline powder … Capecitabine
Active substances (selection) Gadobenic acid Gadobutrol Gadodiamide Gadofosveset Gadoteric acid Gadotenic acid Gadoversetamide Iobitridol Iohexol Iomeprol Iopamidol Iopromide Ioversol Mangafodipir
Products Fondaparinux is commercially available as a solution for injection (Arixtra). It has been approved in many countries since 2002. Structure and properties Fondaparinux (C31H43N3Na10O49S8, Mr = 1728 g/mol) is a synthetic pentasaccharide belonging to the class of glycosaminoglycans. It is present in the drug as fondaparinux sodium. Effects Fondaparinux (ATC B01AX05) has antithrombotic properties. … Fondaparinux
Products Vardenafil is commercially available in the form of film-coated tablets and oral tablets (Levitra, co-marketing drug: Vivanza). It has been approved in many countries since 2003. Generic versions were approved in 2018. Structure and properties Vardenafil (C23H32N6O4S, Mr = 488.6 g/mol) is present in the drugs as vardenafil hydrochloride trihydrate, a piperazine derivative and … Vardenafil
Products Brinzolamide is form of eye drops commercially available (Azopt) and approved in many countries since 1991. Generic versions were released in 2015. Brinzolamide has also been available in a fixed combination with timolol since 2009 (Azarga). In 2015, a fixed combination with brimonidine was approved; see brinzolamide brimonidine (Simbrinza). Structure and properties Brinzolamide (C12H21N3O5S3, … Brinzolamide
Products Amiloride is sold exclusively in fixed combination with the diuretic hydrochlorothiazide in tablet form. The original Moduretic is no longer available in many countries, but generics are available. Structure and properties Amiloride is present in drugs as amiloride hydrochloride (C6H9Cl2N7O – 2 H2O, Mr = 302.1 g/mol) is present, a pale yellow to greenish … Amiloride
Products Naftifine is commercially available as a gel and cream for external use. The drug has not yet been registered in many countries. Structure and properties Naftifine (C21H21N, Mr = 287.4 g/mol) is a lipophilic naphthalene derivative and belongs to the group of allylamines, which includes terbinafine. In pharmaceuticals, it is present as naftifine hydrochloride. … Naftifine
Indications Dementia, e.g., Alzheimer’s disease Agents Cholinesterase inhibitors: Donepezil (Aricept, generics). Galantamine (Reminyl) Rivastigmine (Exelon) NMDA antagonists: Memantine (Axura, Ebixa). Ergot alkaloids: Codergocrine (Hydergine, out of commerce). Smart Drugs Roborantia Phytopharmaceuticals: Ginkgo
Products Heparin sodium is applied primarily as a gel or ointment (eg, HepaGel, Lioton, Demovarin, combination products). This article refers to topical therapy. Heparin sodium is also injected parenterally. Structure and properties Heparin sodium is the sodium salt of a sulfated glycosaminoglycan found in mammalian tissues. It is obtained from the intestinal mucosa of pigs, … Heparin Sodium
Products Ciclesonide is administered with a metered-dose inhaler (Alvesco). It has been approved in many countries since 2006. In the United States, it has also been commercially available as a nasal spray for the treatment of allergic rhinitis since 2012 (Zetonna). Structure and properties Ciclesonide (C32H44O7, Mr = 540.7 g/mol) is a prodrug and is … Ciclesonide
Products Danazol was commercially available in many countries in the form of capsules and had been approved since 1977 (Danatrol). No finished drug products have since been registered. Structure and properties Danazol (C22H27NO2, Mr = 337.5 g/mol) is an isoxazole derivative of ethisterone related to testosterone. Danazol exists as a white to slightly yellow crystalline … Danazol
