Products Famotidine is not commercially available in many countries. In Germany and other countries, it is available in the form of film-coated tablets. Structure and properties Famotidine (C8H15N7O2S3, Mr = 337.4 g/mol) exists as a white to yellowish-white crystalline powder or as crystals and is very sparingly soluble in water. It is a thiazole derivative … Famotidine
Products Chloroquine was commercially available in tablet form (Nivaquine). It was approved in many countries since 1953. Its distribution was discontinued in 2019. It was first synthesized in 1934 by Hans Andersag at Bayer in Elberfeld (I.G. Farbenindustrie). Currently, medicines containing chloroquine are no longer available in many countries. Magisterial formulations can be made in … Chloroquine
Products Sufentanil is commercially available as a solution for injection (Sufenta, generic). It was developed in the 1970s and has been approved in many countries since 1994. Sublingual tablets for pain management are also available in some countries (Dzuveo, Zalviso). Structure and properties Sufentanil (C22H30N2O2S, Mr = 386.6 g/mol) is present in drugs as sufentanil … Sufentanil
Products Pitavastatin is commercially available in the form of film-coated tablets (Livazo). It was first approved in many countries in July 2012. In Japan, it has been on the market since 2003, and it is also available in other countries such as the United States and Germany. Structure and properties Pitavastatin (C25H24FNO4, Mr = 421.5 … Pitavastatin
Products Sertraline is commercially available as film-coated tablets and as an oral concentrate (Zoloft, generic). It was first released in the United States in 1991 and became a blockbuster. It was approved in many countries in 1993. Structure and properties Sertraline (C17H17Cl2N, Mr = 306.2 g/mol) is present in drugs as sertraline hydrochloride, a white … Sertraline
Products Spironolactone is commercially available in film-coated tablet form as a monopreparation (Aldactone) and in fixed combination with furosemide (Furospir). It was developed in the 1950s at G.D. Searle in Chicago and approved in 1959, and in many countries in 1961. Structure and properties Spironolactone (C24H32O4S, Mr = 416.6 g/mol) exists as a white to … Spironolactone
Products Fluconazole is commercially available in capsule form, as a powder for suspension, and as an infusion solution (Diflucan, generic). It has been approved in many countries since 1989. Structure and properties Fluconazole (C13H12F2N6O, Mr = 306.3 g/mol) is a fluorinated triazole derivative. It exists as a white, crystalline and hygroscopic powder that is sparingly … Fluconazole
Products Mast cell stabilizers are commercially available in many countries in the form of eye drops, as nasal sprays, as oral capsules, and as tablets. Several antihistamines also have mast cell stabilizing properties (see there). Structure and properties The typical structural elements of mast cell stabilizers include carboxylic acids. However, the chemical structure of the … Mast Cell Stabilizers
Definition and examples Me-too drugs are imitators of already approved and established drugs, which differ only slightly from their predecessors. Typical drug groups with many me-too drugs are the statins (e.g., pitavastatin), the ACE inhibitors (e.g., zofenopril), the sartans (e.g., azilsartan), and the SSRIs (e.g., vortioxetine). Me-too drugs are not generics, but active ingredients with … Me-Too Drugs
Products Fosamprenavir is commercially available in the form of film-coated tablets (Telzir). It has been approved in many countries since 2005. Structure and properties Fosamprenavir (C25H36N3O9PS, Mr = 585.6 g/mol) is present in drugs as fosamprenavir calcium. It is a prodrug that is rapidly biotransformed in the intestinal mucosa to the active metabolite amprenavir. Amprenavir … Fosamprenavir
Product Phenytoin is commercially available in tablet, injection, and infusion forms (phenhydane, phenytoin gerot). It has been approved in many countries since 1960. Structure and properties Phenytoin or 5,5-diphenylhydantoin (C15H12N2O2, Mr = 252.3 g/mol) exists as a white crystalline powder that is practically insoluble in water. The sodium salt phenytoin sodium, which is present in … Phenytoin: Drug Effects, Side Effects, Dosage and Uses
