Products Benoxaprofen was commercially available in tablet form (Oraflex, Opren) beginning in 1980. It was withdrawn from the market again in August 1982 because of the numerous adverse effects reported. Structure and properties Benoxaprofen (C16H12ClNO3, Mr = 301.7 g/mol) is a chlorinated benzoxazole derivative and exists as a racemate. It belongs to the propionic acid … Benoxaprofen
Products Lysine acetyl salicylate is commercially available as powder and injectable (Aspégic, Alcacyl powder, Germany: e.g., Aspirin i.v., Aspisol). It has been approved in many countries since 1973. Migpriv, which is combined with metoclopramide for migraine, was withdrawn from the market in many countries in December 2011 see under Migpriv. Kardégic was withdrawn from the … Lysine Acetyl Salicylate
Products Most sartans are commercially available as tablets or film-coated tablets. Losartan was the first agent approved in many countries in 1994 (Cosaar, USA: 1995, Cozaar). Sartans are often combined with hydrochlorothiazide fix. The name of the drug group is derived from the suffix -sartan of the active ingredients. The drugs are also called angiotensin … Sartans
Products Carprofen is commercially available in the form of tablets, chewable tablets, and as a solution for injection. It has been approved in many countries since 1998. Structure and properties Carprofen (C15H12ClNO2, Mr = 273.7 g/mol) is an arylpropionic acid derivative. It exists as a white crystalline powder that is practically insoluble in water. Carprofen … Carprofen
Products There are no drugs containing fenbufen on the market in many countries. Brand names include Cinopal and Lederfen, for example. Structure and properties Fenbufen (C16H14O3, Mr = 254.3 g/mol) exists as a white, fine, crystalline powder that is very sparingly soluble in water. It is a biphenyl derivative and belongs to the propionic acid … Fenbufen
Products Bromfenac is commercially available in the form of eye drops (Yellox). It was approved in the United States in 2005 and in the EU in 2011. It was registered in many countries in 2013. Structure and properties Bromfenac (C15H12BrNO3, Mr = 334.2 g/mol) is a benzophenone derivative. It is present in solution in drugs … Bromfenac
Products Cimicoxib is commercially available in the form of chewable tablets for dogs (Cimalgex). It has been approved in many countries since 2011. Structure and properties Cimicoxib (C16H13ClFN3O3S, Mr = 381.8 g/mol) is a chlorinated and fluorinated benzenesulfonamide and imidazole derivative. It has a V-shaped structure like other COX-2 inhibitors, which allows binding to the … Cimicoxib
Products Grapiprant is commercially available in some countries as a veterinary medicine in tablet form for dogs (Galliprant). Structure and properties Grapiprant (C26H29N5O3S, Mr = 491.6 g/mol) Effects Grapiprant (ATCvet QM01AX92) has analgesic and anti-inflammatory properties. The effects are due to selective antagonism at the EP4 receptor and displacement of the natural ligand prostaglandin E2 … Grapiprant
Products Nefopam used to be available in many countries in tablet form (Acupan). It is now no longer commercially available. Structure and properties Nefopam (C17H19NO, Mr = 253.3 g/mol) exists as nefopam hydrochloride, a white crystalline powder that is soluble in water. It is a benzoxazocine derivative. Nefopam is not structurally related to other analgesics. … Nefopam
Products Diclofenac eye drops are commercially available from several manufacturers (Dicloabak, Difen-Stulln, Voltaren Ophtha). They have been approved in many countries since 1994. Because of the potential adverse effects of preservatives on the eye, unpreserved monodoses for single use are also available. Furthermore, dicloabak was launched in many countries in 2012. This is a 10-ml … Diclofenac Eye Drops
Products Tigilanol tiglate was approved in the EU and many countries in 2020 as a solution for injection in dogs (Stelfonta). It is a veterinary medicinal product. Structure and properties Tigilanol tiglate (C30H42O10, Mr = 562.6 g/mol) is a diterpene ester (an epoxytiglian). It is extracted from the seeds of , a shrub or tree … Tigilanol Tiglate
Products In many countries, drugs containing phenacetin are no longer on the market. Structure and properties Phenacetin (C10H13NO2, Mr = 179.2 g/mol) exists as a white crystalline powder that is sparingly soluble in water. Effects Phenacetin has analgesic and antipyretic properties. Indications For the treatment of pain and fever of various causes. Adverse effects Skin … Phenacetin