Products Oritavancin was approved in the United States in 2014 as an infusion preparation (Orbactiv). The drug has not yet been registered in many countries. Structure and properties Oritavancin is present in drugs as oritavancin phosphate (C86H97N10O26Cl3 – 2H3PO4, Mr = 1989.1 g/mol) is present, a complex semisynthetically produced lipoglycopeptide structurally related to other glycopeptide … Oritavancin
Products Ornidazole is commercially available in the form of film-coated tablets and ampoules (Tiberal). It has been approved in many countries since 1980. Vaginal tablets for local treatment of trichomoniasis are out of commerce. Structure and properties Ornidazole (C7H10ClN3O3, Mr = 219.6 g/mol) is a nitroimidazole. Effects Ornidazole (ATC P01AB03, ATC J01XD03) has bactericidal and … Ornidazole
Products Retapamulin is commercially available as an ointment (Altargo). It was approved in the EU in 2007 and in many countries in 2009. Structure and properties Retapamulin is a semisynthetic derivative of pleuromutilin derived from the pillz (cat’s ear). Effects Retapamulin (ATC D06AX13) is bacteriostatic against and by inhibiting bacterial protein synthesis via ribosomal binding. … Retapamulin
Products Vancomycin is commercially available as an injectable and in capsule form (Vancocin, generics). It was discovered in 1957 in soil samples from a jungle in Borneo and has been approved in many countries since 1959. Structure and properties Vancomycin is present in drugs as vancomycin hydrochloride (C66H76Cl3N9O24, Mr = 1486 g/mol) is present, a … Vancomycin
Products Mupirocin is commercially available as creams, ointments, and nasal ointments (Bactroban). It has been approved in many countries since 1988. Structure and properties Mupirocin (C26H44O9, Mr = 500.6 g/mol) is a naturally occurring antibiotic obtained by fermentation from or obtained by other methods. It is present in drugs as the dicalcium salt mupirocin calcium, … Mupirocin
Products Amikacin is commercially available as a solution for injection (Amikin). It has been approved in many countries since 1976. Structure and properties Amikacin (C22H43N5O13, Mr = 585.6 g/mol) is semisynthetically prepared from kanamycin A. It is found in drugs as amikacin sulfate, a white powder that is readily soluble in water. Effects Amikacin (ATC … Amikacin
Effects Aminoglycosides (ATC J01G) have bactericidal properties. They inhibit protein synthesis by bacteria by binding to subunits of ribosomes. Indications Bacterial infectious diseases Special indications (paromomycin) Active ingredients Amikacin Framycetin (= neomycin B) Gentamicin Neomycin Netilmicin Kanamycin (veterinary drug) Paromomycin Streptomycin Tobramycin, tobramycin inhalation, tobramycin eye drops. Aminoglycosides are not available perorally as polycations and … Aminoglycosides
Products Colistimethate is commercially available as a powder for the preparation of a solution for a nebulizer and as a powder for the preparation of an infusion solution for a nebulizer. It has been approved in many countries since 2000. Structure and properties Colistimethate sodium is prepared from colistin by reaction with formaldehyde and sodium … Colistimethate
Products Metronidazole is commercially available for the external treatment of rosacea as a cream (Rosalox, Perilox), a cream tinted with iron oxides (Perilox color), and a gel (Nidazea, Rozex). In some countries, e.g. Germany, a lotion is also available. The effectiveness of the therapy was first demonstrated by Nielsen in 1983. In many countries, the … Metronidazole for the External Treatment of Rosacea
Products Trimethoprim and sulfamethoxazole are commercially available in tablet and syrup form (Bactrim, generics). The drug has been approved in many countries since 1969. The Bactrim syrup is no longer available, but a generic is available (Nopil syrup). The fixed combination of the two active ingredients is also called cotrimoxazole. Structure and properties Trimethoprim (C14H18N4O3, … Trimethoprim and Sulfamethoxazole
Products Silver sulfadiazine is commercially available as creams and gauzes (Flammazine, Ialugen Plus with hyaluronic acid to promote wound healing). It has been approved in many countries since 1974. Structure and properties Sulfadiazine (C10H10N4O2S, Mr = 250.3 g/mol) exists as in the form of crystals or as a crystalline powder with white, yellowish or light … Silver Sulfadiazine
Procedure in the pharmacy Refer to the package insert for each drug. 1. If the suspension is needed immediately, it is prepared by the pharmacist. If this is not desired, it can also be prepared by the parents. General instructions (example!): Shake the bottle with the powder to loosen the powder. Carefully fill with tap … Antibiotic Suspensions for Children
