Products Zoledronic acid is commercially available as an infusion preparation (Zometa, Aclasta, generics). It has been approved in many countries since 2000. Structure and properties Zoledronic acid (C5H10N2O7P2, Mr = 272.1 g/mol) is present in drugs as zoledronic acid monohydrate, a white crystalline powder that is sparingly soluble in water. It is an imidazole derivative … Zoledronic Acid
Products Tin is not commonly used in pharmacy and is usually rarely found in medicines. It is used primarily in alternative medicine in various dosage forms, for example in homeopathy and anthroposophic medicine. This usually under the name Stannum or Stannum metallicum (metallic tin). Also known is the tin ointment (Stannum metallicum unguentum). Tin should … Tin
Products Bisoprolol is commercially available in film-coated tablet form as a monopreparation (Concor, generic) and as a fixed combination with hydrochlorothiazide (Concor plus, generic). It has been approved in many countries since 1986. In 2016, a fixed combination with perindopril was approved (Cosyrel). Structure and properties Bisoprolol (C18H31NO4, Mr = 325.4 g/mol) is present in … Bisoprolol Effects and Side Effects
Products Most ACE inhibitors are commercially available in the form of tablets and film-coated tablets. The first agent from this group to be approved was captopril, in many countries in 1980. ACE inhibitors are often combined with the thiazide diuretic hydrochlorothiazide (HCT) fix. Structure and properties ACE inhibitors are peptidomimetics derived from peptides found in … ACE Inhibitors List, Effects, Side Effects
Products Benzbromarone was withdrawn from the market in many countries in 2003 because of its hepatotoxicity. Desuric and other drugs are no longer available. It is still available in other countries. The withdrawal was not without controversy (Jansen, 2004). Structure and properties Benzobromarone (C17H12Br2O3, Mr = 424.1 g/mol) is a derivative of khellin. It exists … Benzbromarone
Products Retigabine was approved in many countries as film-coated tablets since 2011 (Trobalt). In the United States, it is referred to as ezogabine. It was discontinued in 2017. Structure Retigabine (C16H18FN3O2, Mr = 303.3 g/mol) is a carbamate that was developed starting from the analgesic flupirtine. The free primary amino group is -glucuronidated (see below). … Retigabine (Ezogabine)
Products The fixed combination Deanxit with the two active ingredients melitracene and flupentixol is commercially available in many countries in the form of film-coated tablets. The drug has been approved since 1973, initially as dragées. The marketing authorization holder is the Danish company Lundbeck. Structure and properties The active ingredients are present in the drug … Melitracene and Flupentixol
Products Caplacizumab was approved in many countries in 2019 as a powder and solvent for solution for injection (Cablivi). Structure and properties Caplacizumab is a humanized, bivalent nanobody (single-domain antibody) produced by biotechnological methods. It consists of two building blocks (PMP12A2hum1) linked by a 3-alanine linker. Effects Caplacizumab (ATC B01AX07) binds to the A1 domain … Caplacizumab
Products Isoxsuprin is commercially available as a solution for injection for animals. It has been approved in many countries since 1983. Structure and properties Isoxsuprine (C18H24ClNO3, Mr = 337.8 g/mol) Effects Isoxsuprine (ATCvet QC04AA01) relaxes uterine smooth muscle. Indications Uterine muscle relaxation in cattle, sheep, goats, and swine.
Products Sodium picosulfate is commercially available in the form of tablets, soft capsules (pearls), and drops (e.g., Laxoberon, Dulcolax Picosulfate). It has been approved in many countries since 1973. Structure and properties Sodium picosulfate (C18H13NNa2O8S2, Mr= 481.41 g/mol) is structurally closely related to bisacodyl. The difference is that it is esterified with sulfuric acid instead … Sodium Picosulfate
Products Cortisone Ciba (out of trade) Structure and properties Cortisone acetate (C23H30O6, Mr = 402.5 g/mol) Effects, indications See under glucocorticoids
Products Amiloride is sold exclusively in fixed combination with the diuretic hydrochlorothiazide in tablet form. The original Moduretic is no longer available in many countries, but generics are available. Structure and properties Amiloride is present in drugs as amiloride hydrochloride (C6H9Cl2N7O – 2 H2O, Mr = 302.1 g/mol) is present, a pale yellow to greenish … Amiloride