Products Amiloride is sold exclusively in fixed combination with the diuretic hydrochlorothiazide in tablet form. The original Moduretic is no longer available in many countries, but generics are available. Structure and properties Amiloride is present in drugs as amiloride hydrochloride (C6H9Cl2N7O – 2 H2O, Mr = 302.1 g/mol) is present, a pale yellow to greenish … Amiloride
Effects Aminoglycosides (ATC J01G) have bactericidal properties. They inhibit protein synthesis by bacteria by binding to subunits of ribosomes. Indications Bacterial infectious diseases Special indications (paromomycin) Active ingredients Amikacin Framycetin (= neomycin B) Gentamicin Neomycin Netilmicin Kanamycin (veterinary drug) Paromomycin Streptomycin Tobramycin, tobramycin inhalation, tobramycin eye drops. Aminoglycosides are not available perorally as polycations and … Aminoglycosides
Indications Antihelminthics are used to treat worm infections and, in some cases, protozoa. Active ingredients Imidazoles / benzimidazoles: Mebendazole (Vermox). Pyrantel (Cobantril) Other: Pyrvinium (Pyrcon, Molevac, Germany). Albendazole (Zentel) Aminoglycosides: Paromomycin (Humatin) Other: Ivermectin (Stromectol, import from France, in many countries not in the approved and not on sale). Niclosamide (not commercially available in many … Antihelminthics (Vermifuge)
Products Heparin sodium is applied primarily as a gel or ointment (eg, HepaGel, Lioton, Demovarin, combination products). This article refers to topical therapy. Heparin sodium is also injected parenterally. Structure and properties Heparin sodium is the sodium salt of a sulfated glycosaminoglycan found in mammalian tissues. It is obtained from the intestinal mucosa of pigs, … Heparin Sodium
Products Xylazine is commercially available as a solution for injection. It is approved exclusively as a veterinary drug in many countries and has been since 1970. Structure and properties Xylazine (C12H16N2S, Mr = 220.3 g/mol) is a thiazine derivative. It exists as a white crystalline powder that is readily soluble in water. In veterinary medicine … Xylazine
Products Diflunisal is no longer available in pharmaceuticals in many countries. Unisal is out of commerce. Structure and properties Diflunisal (C13H8F2O3, Mr = 250.2 g/mol) is a derivative of salicylic acid. It exists as a white crystalline powder that is practically insoluble in water. Effects Diflunisal (ATC N02BA11) is analgesic, antipyretic, and anti-inflammatory. Indications Pain, … Diflunisal
Products Tisagenlecleucel (Kymriah, cell suspension for infusion) was approved as the first gene therapy in the United States in 2017 and in the EU and many countries in 2018. The drug was originally developed by Novartis at the University of Pennsylvania. The high price of the therapy is controversial. Mechanism of action Tisagenlecleucel is a … Tisagenlecleucel
Effects Indirect dopaminergic Indications Parkinson’s disease Depression (USA) Active ingredients Rasagiline (Azilect) Selegiline (off label) Safinamide (Xadago)
Products Alprostadil cream Vitaros was approved in many countries in 2016. It is an export approval. In some countries, it is marketed as Virirec. Structure and properties Alprostadil (C20H34O5, Mr = 354.5 g/mol) exists as a white to slightly yellowish crystalline powder that is practically insoluble in water. The substance structurally corresponds to natural prostaglandin … Alprostadil Cream
Products Paliperidone is commercially available as sustained-release tablets (Invega, generic) and as a sustained-release suspension for intramuscular injection (Xeplion, Trevicta, generic). It has been approved in many countries since 2008. Structure and properties Paliperidone (C23H27FN4O3, Mr = 426.5 g/mol) exists as a racemate and is practically insoluble in water. It belongs to the group of … Paliperidone
Products Teflubenzuron is commercially available in many countries as a powder in combination with diflubenzuron (Koi Med Louse-Ex). It has been approved in many countries since 2008. Structure and properties Teflubenzuron (C14H6Cl2F4N2O2, Mr = 381.1 g/mol) is a benzoylphenylurea derivative. It is structurally closely related to lufenuron (Program). Effects Teflubenzuron (ATCvet QP53AX30) inhibits parasite development … Teflubenzuron
Products Celecoxib is commercially available in capsule form (Celebrex, generic). It was approved in many countries in 1999 as the first member of the selective COX-2 inhibitors. Generic versions went on sale in 2014. Structure and properties Celecoxib (C17H14F3N3O2S, Mr = 381.37 g/mol) is a benzenesulfonamide and a substituted diaryl pyrazole. It has a V-shaped … Celecoxib
