Products The fixed combination Pylera with the active ingredients bismuth, metronidazole, and tetracycline was approved in many countries in 2017 in the form of hard capsules. In some countries, it was available much earlier, for example, in the United States since 2006. This treatment is the so-called bismuth quadruple therapy (“BMTO”), which was developed by … Bismuth, Metronidazole, Tetracycline
Products Propiverine was approved in many countries in 2020 in the form of modified-release hard capsules (Mictonorm). Later, coated tablets were also registered (Mictonet). This is an older active ingredient that was available earlier in Germany, for example. Structure and properties Propiverine (C23H29NO3, Mr = 367.5 g/mol) is present in drugs as propiverine hydrochloride. Active … Propiverine
Products Ferric maltol is commercially available in the form of hard capsules (Feraccru, some countries: Accrufer). It was approved in the EU in 2016 and in many countries in 2017. Structure and properties Ferric maltol contains ferric ions in a complex with three molecules of maltol (ferric trimaltol). Due to the complexation, iron is better … Iron Maltol
Products Eliglustat is commercially available in the form of hard capsules (Cerdelga). It was approved in many countries in 2020. Structure and properties Eliglustat (C23H36N2O4, Mr = 404.5 g/mol) is present in the drug as eliglustat tartrate. Eliglustat is an analog of glucocerebroside. Effects Eliglustat (ATC A16AX10) is a specific inhibitor of the enzyme glucosylceramide … Eliglustat
Products Lenalidomide is commercially available in the form of hard capsules (Revlimid). It has been approved in many countries since 2007. Generic versions were registered in 2019. Structure and properties Lenalidomide (C13H13N3O3, Mr = 259.3 g/mol) is a derivative of thalidomide and exists as a racemate. Effects Lenalidomide (ATC L04AX04) has immunomodulatory and antiangiogenic properties. … Lenalidomide
Products Mercaptamine was approved in many countries in 2019 in the form of hard capsules (Procysbi). The active ingredient is also known as cysteamine or cysteamines. In 2020, eye drops were approved for the treatment of cystine deposits in the cornea (Cystadrops). This article refers to the capsules. Structure and properties Mercaptamine (C2H7NS, Mr = … Mercaptamine
Products Niraparib was approved in the US and EU in 2017 and in many countries in 2018 in hard capsule form (Zejula). Structure and properties Niraparib (C19H20N4O, Mr = 320.4 g/mol) is present in the drug as niraparibtosilate monohydrate. It is a piperidine, indazole, and carboxamide derivative. Effects Niraparib (ATC L01XX54) has antitumor and cytotoxic … Niraparib
Products Talazoparib is commercially available in hard capsule form (Talzenna). It was approved in the United States in 2018 and in the EU and many countries in 2019. Structure and properties Talazoparib exists in the drug as talazoparib tosilate, a white to yellow solid. Fluorination of the drug prevents oxidative metabolism. Effects Talazoparib (ATC L01XX60) … Talazoparib
Products Dabrafenib was approved in the US and EU in 2013 and in many countries in 2014 in hard capsule form (Tafinlar). Structure and properties Dabrafenib (C23H20F3N5O2S2, Mr = 519.6 g/mol) is present in drugs as dabrafenib mesilate, a white to slightly colored powder that is practically insoluble in water. It is a thiazole and … Dabrafenib
Products Pirfenidone is commercially available in the form of hard capsules and film-coated tablets (Esbriet). It was approved in Japan in 2008 (Pirespa), in the EU in 2011, in the United States in 2014, and in many countries in 2015. Structure and properties Pirfenidone or 5-methyl-1-phenyl-2-1(H)-pyridone (C12H11NO, Mr = 185.2 g/mol) is a phenylpyridone. It … Pirfenidone
Products Doxylamine is commercially available in many countries as a solution (Sanalepsi N). It is also contained in Vicks MediNait juice in combination with dextromethorphan, ephedrine, and acetaminophen. In 2020, hard capsules containing doxylamine and pyridoxine were approved in many countries for the treatment of nausea and vomiting in pregnancy (Cariban). Pharmacies also make a … Doxylamine
Products Indacaterol is commercially available as hard capsules with a powder for inhalation (Onbrez Breezhaler) and has been approved since 2010. It is also combined fixed with the LAMA glycopyrronium bromide (Ultibro Breezhaler, approved 2014). The fixed combination with mometasone furoate (Atectura Breezhaler) was registered for asthma therapy in 2020. Finally, a combination of indacaterol … Indacaterol
