Effects Positive inotropic (hermuscular contractility). Negative chronotropic (heart rate) Negative dromotropic (excitation conduction) Positive bathmotropic (stimulus threshold is lowered). Indications Heart failure Arrhythmia Agents Digoxin (Digoxin Sandoz) Digitoxin Other active ingredients such as convallatoxin or proscillaridin are no longer commercially available today. Stem plants Adonis Christmas rose Foxglove, see under red foxglove Lily of the … Cardiac Glycosides
Products Glucarpidase is commercially available in the United States as an injectable (Voraxaze). The drug has not yet been approved in many countries. Structure and properties Glucarpidase is a carboxypeptidase biotechnologically derived from genetically modified. It is protein composed of 390 amino acids and exists as a homodimer with a molecular weight of 83 kDa. … Glucarpidase
Products Terlipressin is commercially available as an injectable (glypressin, haemopressin). It has been approved in many countries since 1982. Structure and properties Terlipressin (triglycyl lysine vasopressin) is a synthetic analog of vasopressin, the antidiuretic hormone (ADH). It differs from ADH in four amino acids: Terlipressin: Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly ADH: Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly. Effects Terlipressin (ATC H01BA04) has vasoconstrictor properties, … Terlipressin
Products Rifabutin is commercially available in capsule form (mycobutin). It has been approved in many countries since 1994. Structure and properties Rifabutin (C46H62N4O11, Mr = 847 g/mol ) is a semisynthetic ansamycin antibiotic. It exists as a reddish purple amorphous powder that is sparingly soluble in water. Effects Rifabutin (ATC J04AB04) has antibacterial properties against … Rifabutin
Products Ibuprofen sodium was commercially available in many countries in the form of film-coated tablets (Saridon /-forte). Meanwhile, Saridon contains ibuprofen rather than the sodium salt (Saridon neo). Structure and properties Ibuprofen sodium (C13H21NaO4, Mr = 264.3 g/mol) is the salt of the analgesic ibuprofen with sodium. It exists as ibuprofen sodium dihydrate (2 H2O). … Ibuprofen Sodium
Products Lansoprazole is commercially available in the form of capsules as meltable tablets (Agopton, generics). It has been approved in many countries since 1993. Structure and properties Lansoprazole (C16H14F3N3O2S, Mr = 369.4 g/mol) is a benzimidazole and pyridine derivative. It exists as a white to brownish-white, odorless, crystalline powder that is practically insoluble in water. … Lansoprazole
Products Sarecycline was approved in the United States in 2018 in tablet form (Seysara). Structure and properties Sarecycline (C24H29N3O8, Mr = 487.5 g/mol) is structurally related to other tetracyclines. Effects Sarecycline has antibacterial effects against and anti-inflammatory properties. Unlike other tetracyclines, it has a narrow spectrum of activity and therefore has a lesser negative effect … Sarecycline
Products Alogliptin is commercially available in film-coated tablet form as a monopreparation (Vipidia) and as a fixed combination with metformin (Vipdomet). It was approved in many countries in 2013. Structure and properties Alogliptin (C18H21N5O2, Mr = 339.4 g/mol) is present in drugs as alogliptin benzoate, a white crystalline powder that is sparingly soluble in water. … Alogliptin
Products Flecainide is commercially available as tablets and as a solution for injection (Tambocor). It has been approved in many countries since 1984. Structure and properties Flecainide (C17H20F6N2O3, Mr = 414.3 g/mol) is present in drugs as flecainide acetate, a white, crystalline, and very hygroscopic powder that is soluble in water. It is an amide-type … Flecainide
