Products Buformin (Silubin retard, dragées) is no longer commercially available in many countries and many more because of the potential adverse effects. Structure and properties Buformin (C6H15N5, Mr = 157.2 g/mol) is a 1-butylbiguanide with a similar structure to metformin from the same drug group. It is present in drugs as buformin hydrochloride. Effects Buformin … Buformin
Products Clascoterone was approved as a cream in the United States in 2020 (Winlevi). Structure and properties Clascoterone (C24H34O5, Mr = 402.5 g/mol) corresponds to the steroid cortexolone-17α-propionate. It exists as a white powder that is practically insoluble in water. Effects Clascoterone has antiandrogenic properties. The effects are due to antagonism at androgen receptors. Androgens … Clascoteron
Products Bumetanide was commercially available in tablet form (Burinex, off label). It was approved in many countries in 1974. Structure and properties Bumetanide (C17H20N2O5S, Mr = 364.4 g/mol) is a white crystalline powder that is practically insoluble in water. Effects Bumetanide (ATC C03CA02) is diuretic with rapid onset and short duration of action. Indications Oedema … Bumetanide
Products No drugs containing clebopride are on the market in many countries. Structure and properties Cleboprid (C20H24ClN3O2, Mr = 373.9 g/mol) is present in drugs as clebopride malate, a white crystalline powder that is sparingly soluble in water. Clebopride is a substituted benzamide. Effects Clebopride (ATC A03FA06) has prokinetic and antiemetic properties. Indications For the … Cleboprid
Products Bunazosin is commercially available in the form of sustained-release tablets (Andante). The drug is not registered in many countries. Structure and properties Bunazosin (C19H27N5O3, Mr = 373.4 g/mol) is present in drugs as bunazosin hydrochloride. It is a quinazoline derivative. Effects Bunazosin (ATC C02CA) is antihypertensive. Its effects are due to selective and competitive … Bunazosin
Products Clemastine is commercially available in tablet form and as a solution for injection (Tavegyl). It has been approved in many countries since 1967. Tavegyl gel has been off the market since 2010 because of low demand. It can be replaced, for example, by a dimetindene maleate gel (Fenistil). Structure and properties Clemastine (C21H26ClNO, Mr … Clemastine
Products Buphenin was included in Arbid drops in combination with diphenylpyralin until late 2011. Structure and properties Buphenin (C19H25NO2, Mr = 299.41 g/mol), like other sympathomimetics, has structural similarity to catecholamines, for example, epinephrine. Effects Buphenine (ATC C04AA02) is β-sympathomimetic and thus vasodilatory and positively inotropic. Indications No longer commercially available in many countries for … Buphenin
Products Clenbuterol is not commercially available as a human drug in many countries, but exclusively as a veterinary drug for the treatment of respiratory diseases (e.g., Ventipulmin ad us vet). It is available only on medical prescription. In other countries, clenbuterol is on the market in tablet and drop form (Spiropent). Structure and properties Clenbuterol … Clenbuterol
