Products The marketing of medicinal products containing dihydroergotamine has been discontinued in many countries (e.g., Dihydergot tablets and nasal spray, Ergotonin, Effortil plus, Old Tonopan, and others). The approval of Dihydergot tablets was cancelled on February 1, 2014, because the benefits no longer outweighed the potential risks, according to drug regulators. Structure and properties Dihydroergotamine … Dihydroergotamine
Products Risankizumab was approved in the United States and in many countries in 2019 as a solution for injection (Skyrizi). Structure and properties Risankizumab is a humanized IgG1 monoclonal antibody produced by biotechnological methods. Effects Risankizumab (ATC L04AC) has selective immunosuppressive and anti-inflammatory properties. The antibody binds to the p19 subunit of human interleukin-23 (IL-23), … Risankizumab
Products Pyrvinium is commercially available as an oral suspension and in the form of dragées. It is no longer available in many countries. Structure and properties Pyrvinium (C26H28N3+, Mr = 382.5 g/mol) is present in pharmaceuticals as pyrvinium embonate or pyrvinium pamoate. Pyrvinium embonate is an orange-red to orange-brown powder with almost no odor and … Pyrvinium
Products Amsacrine is commercially available as an infusion preparation (Amsidyl). It has been approved in many countries since 1993. Structure and properties Amsacrine (C21H19N3O3S, Mr = 393.5 g/mol) is an aminoacridine derivative. Effects Amsacrine (ATC L01XX01) has antineoplastic properties. The effects are due to inhibition of topoisomerase II. As a result, DNA synthesis is blocked. … Amsacrine
Products Cathinone is not approved as a drug in many countries and is therefore not commercially available. It is one of the banned narcotics (d). In recent years, there have been increasing reports of synthetic cathinone derivatives (designer drugs) such as mephedrone and MDPV, which were initially sold legally as fertilizer and bath salts. Legislation … Cathinon
Products Dextropropoxyphene is no longer on sale in many countries. Depronal retard, Distalgesic, and other drugs are no longer available. According to the French medicines agency AFSSAPS, the active ingredient is also being withdrawn from the market in the EU. Structure and properties Dextropropoxyphene hydrochloride (C22H30ClNO2, Mr = 375.9 g/mol) is a white crystalline powder … Dextropropoxyphene
Products Octocog alfa is commercially available as an injectable. It has been approved in many countries since 2004. Structure and properties Octocog alfa is the recombinant blood clotting factor VIII produced by biotechnological methods. In the past, it was also obtained from plasma, but this posed a risk for the transmission of infectious diseases. Octocog … Octocog Alfa
Products Tacalcitol is commercially available as an ointment and lotion (Curatoderm). It has been approved in many countries since 1995. Structure and properties Tacalcitol (C27H44O3, Mr = 416.6 g/mol) is a derivative of vitamin D3. It is lipophilic and is present in drugs as tacalcitol monohydrate. Effects Tacalcitol (ATC D05AX04) inhibits the proliferation of keratinocytes … Tacalcitol
Products In many countries, drugs containing butalbital are no longer approved (e.g., Cafergot-PB). Combination products are still on the market in some countries, including the United States, where numerous products are available. Structure and properties Butalbital (C11H16N2O3, Mr = 224.3 g/mol) or 5-allyl-5-isobutylbarbituric acid exists as a slightly bitter, white, odorless, crystalline powder that is … Butalbital
Products Dasabuvir is commercially available in the form of film-coated tablets. It was approved in many countries in 2014 (Exviera). Structure and properties Dasabuvir (C26H27N3O5S, Mr = 493.6 g/mol) has a non-nucleoside structure. It exists in the drug as a sodium salt and as a monohydrate. Effects Dasabuvir (ATC J05AX16) has antiviral properties. The effects … Dasabuvir
Products Alfacalcidol is commercially available in Germany in the form of soft capsules, drops, and as a solution for injection (e.g., EinsAlpha). It is not registered in many countries. Structure and properties Alfacalcidol (C27H44O2, Mr = 400.6 g/mol) corresponds to 1-hydroxycholecalciferol. It is in the form of white crystals and is practically insoluble in water. … Alfacalcidol
Products Dimethyl sulfoxide is approved as a drug in many countries and is sold exclusively in combination with other active ingredients. They are sprays, gels and creams. DMSO ointment 50% is produced in pharmacies. The pure substance is available in pharmacies and drugstores. Medicines for ingestion are not released. The metabolite MSM is available as … Dimethyl Sulfoxide (DMSO)
