Products Dinoprostone is commercially available as a vaginal insert and vaginal tablet (Propess, Prostin E2). It is also available as a vaginal gel and vaginal suppository in some countries. Dinoprostone has been approved in many countries since 1986. Structure and properties Dinoprostone (C20H32O5, Mr = 352.5 g/mol) corresponds to the natural prostaglandin E2. It exists … Dinoprostone
What is phospholipase? Phospholipase is an enzyme that splits fatty acids from phospholipids. The more precise classification is made into four main groups. Besides phospholipids, other lipophilic (fat-loving) substances can be split by the enzyme. The enzyme belongs to the group of hydrolases. This means that one molecule of water is consumed during the process … Phospholipase
Where are they produced? Preliminary stages of phospholipases are synthesized by the ribosomes of the cells. These are located on the cell organelle endoplasmic reticulum of all cells of the body. When they are active, they release a chain of amino acids, which later form the finished enzyme, into the endoplasmic reticulum. Here the enzyme … Where are they produced? | Phospholipase
Products Alprostadil is commercially available as an injectable, urethral rod, and infusion concentrate (Caverject, Muse, Prostin VR). It has been approved in many countries since 1983. An alprostadil cream is also approved in some countries. Structure and properties Alprostadil (C20H34O5, Mr = 354.5 g/mol) is a white to slightly yellowish crystalline powder that is practically … Alprostadil
Products Alprostadil cream Vitaros was approved in many countries in 2016. It is an export approval. In some countries, it is marketed as Virirec. Structure and properties Alprostadil (C20H34O5, Mr = 354.5 g/mol) exists as a white to slightly yellowish crystalline powder that is practically insoluble in water. The substance structurally corresponds to natural prostaglandin … Alprostadil Cream
Products Nonsteroidal anti-inflammatory drugs (NSAIDs) are available in numerous dosage forms. These include film-coated tablets, tablets, sustained-release tablets, oral suspensions, oral granules, suppositories, NSAID eye drops, lozenges, emulsifying gels, and creams (selection). The first active ingredient from this group was salicylic acid, which was used medicinally in the 19th century in the form of the … NSAID
Products Etoricoxib is commercially available in the form of film-coated tablets (Arcoxia). It has been approved in many countries since 2009. Generics were registered in 2020. Structure and properties Etoricoxib (C18H15ClN2O2S, Mr = 358.8 g/mol) has a similar V-shaped structure to other COX-2 inhibitors. It is a dipyridinyl derivative with a methylsulfonyl group. Effects Etoricoxib … Etoricoxib
Products Diclofenac is commercially available in the form of tablets, capsules, soft capsules (liquid caps), dragées, drops, suppositories, as a solution for injection, gel, patches, and eye drops (Voltaren, generics), among others. The analgesic has been approved in many countries since 1974. This article refers to peroral use. For more information, see also diclofenac gel, … Diclofenac: Drug Effects, Side Effects, Dosage and Uses
Products Diclofenac injection solution is available from several suppliers (Voltaren, generics). It has been approved in many countries since 1975. Structure and properties Diclofenac (C14H11Cl2NO2, Mr = 296.15 g/mol) is present in the drug as diclofenac sodium, a white to slightly yellowish, crystalline and weakly hygroscopic powder, which are sparingly soluble in water. Within the … Diclofenac Injection
Products Mifepristone is commercially available in tablet form (Mifegyne). It was first approved in 1988 and in many countries in 1999. Mifepristone was discovered in the 1980s at Roussel-Uclaf (RU) during the development of antiglucocorticoid agents and is therefore also known as RU 486. Structure and properties Mifepristone (C29H35NO2, Mr = 429.6 g/mol) is a … Mifepristone
Symptoms The most common symptoms include cramping or dull abdominal pain. In addition, numerous other symptoms may occur, such as headache, menstrual migraine, back pain, pain in the legs, loss of appetite, nausea and vomiting, diarrhea, weakness, dizziness, flushing of the skin, flushing, sleep disturbances, mood swings, depression, irritability, and nervousness. The symptoms first appear … Menstrual Cramps
Products Piroxicam was commercially available in many countries in the form of a gel (Felden Gel). It had been approved in many countries since 1986. It was discontinued in 2018. Structure and properties Piroxicam (C15H13N3O4S, Mr = 331.4 g/mol) exists as a white to pale yellow crystalline powder that is practically insoluble in water. It … Piroxicam Gel
