Products Ozenoxacin was approved in the United States in 2017 as a cream (Xepi). Structure and properties Ozenoxacin (C21H21N3O3, Mr = 363.4 g/mol) exists as a white to slightly yellow powder. Unlike most quinolones, it is not fluorinated. Ozenoxacin carries a pyridinyl group at position C-7. Effects Ozenoxacin has bactericidal properties and is effective against … Ozenoxacin
Effects P2Y12 antagonists are antiplatelet agents and prevent the formation of blood clots. The effects are due to binding to the adenosine diphosphate receptor P2Y12 on platelets. This receptor plays a central role in glycoprotein (GP)-IIb/IIa activation and platelet aggregation. The continuous binding of adenosine diphosphate (ADP) to P2Y12 is an important prerequisite for thrombus … P2Y12 Antagonists
Products Alirocumab was approved in the United States in 2015 as the first agent in the group of PCSK9 inhibitors in the form of a solution for injection (Praluent). Evolocumab (Repatha) followed as the second agent in the EU, also in 2015. Structure and properties PCSK9 inhibitors to date are monoclonal antibodies that must be … PCSK9 Inhibitors
Products Deflazacort is commercially available in tablet form (Calcort). It has been approved in many countries since 1986. Structure and properties Deflazacort (C25H31NO6, Mr = 441.5 g/mol) differs from prednisolone in having an oxazoline ring at C16-C17. Effects Deflazacort (ATC H02AB13) has anti-inflammatory, antiallergic, and immunosuppressive properties. The mineralocorticoid effect of deflazacort is very low. … Deflazacort
Products Buflomedil is no longer available as a drug in many countries. Loftyl is out of commerce. Structure and properties Buflomedil (C17H25NO4, Mr = 307.4 g/mol) exists as a white, microcrystalline powder that is readily soluble in water. Effects Buflomedil (ATC C04AX20) is vasoactive and α-adrenolytic. It inhibits platelet aggregation, improves erythrocyte deformability and regional … Buflomedil
Products Citrulline is commercially available in the form of sachets containing a drinkable solution (Biostimol). It has been approved in many countries since 1996. Structure and properties L-(+)-citrulline (C6H13N3O3, Mr = 175.2 g/mol) exists as a white crystalline powder that is readily soluble in water. Citrulline is an amino acid found, for example, in watermelon. … Citrulline
Products Buformin (Silubin retard, dragées) is no longer commercially available in many countries and many more because of the potential adverse effects. Structure and properties Buformin (C6H15N5, Mr = 157.2 g/mol) is a 1-butylbiguanide with a similar structure to metformin from the same drug group. It is present in drugs as buformin hydrochloride. Effects Buformin … Buformin
Products Cladribine was approved for the treatment of multiple sclerosis in the EU in 2017 and in the United States and many countries in 2019 in tablet form (Mavenclad). Cladribine has also been commercially available as an infusion and injection solution in many countries since 1998 (Litak). This article relates to MS therapy. Structure and … Cladribine
Products Bumetanide was commercially available in tablet form (Burinex, off label). It was approved in many countries in 1974. Structure and properties Bumetanide (C17H20N2O5S, Mr = 364.4 g/mol) is a white crystalline powder that is practically insoluble in water. Effects Bumetanide (ATC C03CA02) is diuretic with rapid onset and short duration of action. Indications Oedema … Bumetanide
Products Clarithromycin is commercially available as film-coated tablets, sustained-release tablets, oral suspension, and powder for solution for infusion (Klacid, generics). It has been approved in many countries since 1990. Clarithromycin should not be confused with ciprofloxacin. Structure and properties Clarithromycin (C38H69NO13, Mr = 747.96 g/mol) exists as a white crystalline powder that is practically insoluble … Clarithromycin
Products Bunazosin is commercially available in the form of sustained-release tablets (Andante). The drug is not registered in many countries. Structure and properties Bunazosin (C19H27N5O3, Mr = 373.4 g/mol) is present in drugs as bunazosin hydrochloride. It is a quinazoline derivative. Effects Bunazosin (ATC C02CA) is antihypertensive. Its effects are due to selective and competitive … Bunazosin
Products Clascoterone was approved as a cream in the United States in 2020 (Winlevi). Structure and properties Clascoterone (C24H34O5, Mr = 402.5 g/mol) corresponds to the steroid cortexolone-17α-propionate. It exists as a white powder that is practically insoluble in water. Effects Clascoterone has antiandrogenic properties. The effects are due to antagonism at androgen receptors. Androgens … Clascoteron
