Products Travoprost is commercially available in the form of eye drops as a monopreparation (Travatan) and as a fixed combination with the beta-blocker timolol (Duotrav). It was approved in many countries in 2002. Generic versions were first released in 2016 and went on sale in 2017. Structure and properties Travoprost (C26H35F3O6, Mr = 500.55 g/mol) … Travoprost
Products Nepafenac is commercially available as an eye drop suspension in two different concentrations (Nevanac). It has been approved in many countries since 2008. Structure and properties Nepafenac (C15H14N2O2, Mr = 254.3 g/mol) exists as a yellow powder. It is an amide analog and a prodrug of amfenac. It passes rapidly through the cornea and … Nepafenac
Products Epinastine is commercially available in the form of eye drops (Relestat). It has been approved in many countries since 2004. Structure and properties Epinastine (C16H15N3, Mr = 249.31 g/mol) is present in drugs as epinastine hydrochloride. It is an azepine and imidazole derivative. Effects Epinastine (ATC S01GX10) has antihistamine, antiallergic, and mast cell stabilizing … Epinastine
Products Pilocarpine eye drops have been approved in many countries since 1960 (Spersacarpine). The combination with carteolol is off-label (Arteopilo). See also under pilocarpine tablets. Structure and properties Pilocarpine (C11H16N2O2, 208.26 g/mol) is present in the drops as pilocarpine hydrochloride, a white powder or colorless crystals that are very soluble in water. Pilocarpine is an … Pilocarpine Eye Drops
Products Tobramycin eye drops have been approved in many countries since 1982 (Tobrex). The antibiotic is also combined with dexamethasone fixed (Tobradex). Tobrex is also commercially available as an eye ointment and as an eye gel. Structure and properties Tobramycin (C18H37N5O9, Mr = 467.51 g/mol) is obtained from or can be prepared by other methods. … Tobramycin Eye Drops
Products Apraclonidine is commercially available in the form of eye drops (iopidine). It has been approved in many countries since 1995. Structure and properties Apraclonidine (C9H10Cl2N4, Mr = 245.1 g/mol) is an amino derivative of clonidine. It is present in the drug as apraclonidine hydrochloride, a white powder that is highly soluble in water. Effects … Apraclonidine
Products Proxymetacaine is commercially available in the form of eye drops (Alcaine). It has been approved in many countries since 1996. Structure and properties Proxymetacaine (C16H26N2O3, Mr = 294.4 g/mol) is present in drugs as proxymetacaine hydrochloride. It belongs to the ester-type local anesthetics and is structurally related to procaine. Effects Proxymetacaine (ATC S01HA04) has … Proxymetacaine
Products Tafluprost is available in the form of eye drops (saflutane). It was approved in many countries in 2010. In 2016, a fixed combination with timolol was also registered (Taptiqom). Structure and properties Tafluprost (C25H34F2O5, Mr = 452.53 g/mol) is a fluorinated analog of prostaglandin F2α (Figure). It is a prodrug and is converted at … Tafluprost
Products Diclofenac eye drops are commercially available from several manufacturers (Dicloabak, Difen-Stulln, Voltaren Ophtha). They have been approved in many countries since 1994. Because of the potential adverse effects of preservatives on the eye, unpreserved monodoses for single use are also available. Furthermore, dicloabak was launched in many countries in 2012. This is a 10-ml … Diclofenac Eye Drops
Products Fluorometholone is commercially available in the form of eye drops (FML Liquifilm). A fixed combination with neomycin (FML-Neo Liquifilm) is also available. Fluorometholone has been approved in many countries since 1973. Structure and properties Fluorometholone (C22H29FO4, Mr = 376.5 g/mol) is a fluorinated and lipophilic glucocorticoid structurally related to progesterone. It is present in … Fluorometholone
Effects Glucocorticoid eye drops have anti-inflammatory, antiallergic, and immunosuppressive properties on the eye. They may increase intraocular pressure and promote infection. Indications Glucocorticoid eye drops are approved for the treatment of noninfectious inflammatory diseases of the anterior segments of the eye. They are also used in combination with antibiotics for infectious diseases of the eye. … Glucocorticoid Eye Drops
Products Dorzolamide is commercially available in the form of eye drops (Trusopt). Fixed combinations with timolol (Cosopt) and generics are also available. Dorzolamide has been approved in many countries since 1995. Structure and properties Dorzolamide (C10H16N2O4S3, Mr = 324.4 g/mol) is a sulfonamide. It is present in drugs as dorzolamide hydrochloride, a white crystalline powder … Dorzolamide