Products Enfuvirtide is commercially available as a powder and solvent for the preparation of a solution for injection (Fuzeon). It has been approved in many countries since 2003. Structure and properties Enfuvirtide (C 204 H 301 N 51 O 64 , M r = 4492 g/mol) is a linear synthetic peptide composed of 36 natural … Enfuvirtide
Products Ketamine is commercially available as a solution for injection (Ketalar, generic). It has been approved in many countries since 1969. Esketamine nasal spray was approved in 2019 (Switzerland: 2020) for the treatment of treatment-resistant depression (see there). Structure and properties Ketamine (C13H16ClNO, Mr = 237.7 g/mol) is a cyclohexanone derivative derived from phencyclidine (“angel … Ketamine: Drug Effects, Side Effects, Dosage and Uses
Products Methadone is commercially available as tablets, injectable solution, and oral solution (e.g., Ketalgin, Methadone Streuli). Methadone solutions are also prepared in pharmacies as extemporaneous preparations. Structure and properties Methadone (C21H27NO, Mr = 309.45 g/mol) is a synthetically prepared derivative of pethidine, which is itself a derivative of atropine. It is chiral and exists as … Methadone
Products Pegfilgrastim is commercially available as a solution for injection in the form of prefilled syringes (Neulasta). It has been approved in many countries since 2003. Biosimilars have been approved. Structure and properties Pegfilgrastim is a conjugate of filgrastim with a single 20-kDa polyethylene glycol (PEG) molecule. Filgrastim is a protein of 175 amino acids … Pegfilgrastim
Products Peginterferon beta-1a is commercially available as a solution for injection in a prefilled syringe (Plegridy). It was approved in many countries in 2015. Structure and properties Peginterferon beta-1a is a covalent conjugate of interferon beta-1a (Rebif) and methoxypolyethylene glycol with methylpropionaldehyde as a linker. Effects Peginterferon beta-1a (ATC L03AB13) has antiviral, antiproliferative, antitumor, and … Peginterferon Beta-1A
Products Guselkumab was approved in the United States and the EU in 2017 and in many countries in 2018 as a solution for injection for subcutaneous use (Tremfya). Structure and properties Guselkumab is an IgG1λ monoclonal antibody produced by biotechnological methods. Effects Guselkumab (ATC L04AC16) has anti-inflammatory and immunosuppressive properties. The effects are due to … Guselkumab
Products Tolfenamic acid is commercially available as tablets and as a solution for injection as a veterinary drug. It has been approved in many countries since 1997. Structure and properties Tolfenamic acid (C14H12ClNO2, Mr = 261.7 g/mol) is an anthranilic acid derivative and therefore has a similar structure to mefenamic acid (Ponstan, generic). The aminobenzoic … Tolfenamic Acid
Products Brivaracetam was approved in the EU, the United States, and many countries in 2016 in the form of film-coated tablets, oral solution, and solution for injection (Briviact). Structure and properties Brivaracetam (C11H20N2O2, Mr = 212.3 g/mol) is structurally and pharmacologically closely related to levetiracetam (Keppra, generics). Like levetiracetam, it is a pyrrolidinone derivative. Effects … Brivaracetam
Products Amikacin is commercially available as a solution for injection (Amikin). It has been approved in many countries since 1976. Structure and properties Amikacin (C22H43N5O13, Mr = 585.6 g/mol) is semisynthetically prepared from kanamycin A. It is found in drugs as amikacin sulfate, a white powder that is readily soluble in water. Effects Amikacin (ATC … Amikacin
Products Clonidine is commercially available in many countries as tablets and as a solution for injection and has been approved since 1970 (Catapresan). In some countries, clonidine is approved for the treatment of ADHD (eg, Kapvay sustained-release tablets). This article refers to its use in ADHD. Structure and Properties Clonidine (C9H9Cl2N3, Mr = 230.1 g/mol) … Clonidine: Drug Effects, Side Effects, Dosage and Uses
Products Isoprenaline was newly approved in many countries in the fall of 2010 as a solution for injection/concentrate for the preparation of an infusion solution (Isuprel). Structure and properties Isoprenaline (C11H17NO3, Mr = 211.3 g/mol) is a methyl derivative of epinephrine and a racemate. It is present in the drug as isoprenaline hydrochloride, a white … Isoprenaline
Products Insulin degludec is commercially available as a solution for injection (Tresiba). It is also combined fixed with insulin aspart (Ryzodeg, see under IDegAsp). It was newly approved in many countries in March 2013. In 2014, a fixed combination with liraglutide was registered (Xultophy); see under IDegLira. Structure and properties Insulin degludec has essentially the … Insulin Degludec
